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Fluorinated building blocks for organic synthesis and macromolecule synthesis
Synthesis of trifluoromethylated alkylboron compounds and incorporation into small molecules and macromolecules
Fluorinated macromolecules are widely utilized in industry, with the most notable example being Teflon, or perfluorotetrafluoroethylene (PTFE). Additionally, methods for incorporating CF3 into small organic molecules are not well developed, but are needed to expand the chemical repertoire for fluorine incorporation into pharmaceuticals, agrochemicals, and materials.
Researchers in the Molander Lab have developed a metal-free synthetic route to incorporate CF3 groups and other fluorinated alkyl chains into small molecules as well as macromolecules using organoboron intermediates to generate newfound, polyfluorinated entities. These organoboron building blocks are bench-stable, with indefinite shelf-life. The synthetic methods developed allow the introduction of CF3 at sp3-hybridized centers via a novel carbon-carbon bond connection.
Low surface tension and coefficient of friction
High chemical and thermal stability
More readily soluble than existing fluoropolymers
Excellent dielectric properties
Physical properties potentially superior to Teflon / PTFE
Bench-stable, trifluoromethylated building blocks for pharmaceutical and agrochemical applications
Stage of Development:
Ryu D. et al.
Chem. Eur. J.,
2016, 22, p. 120-133.
Molander G.A. and Ryu D.
2014, 53(51), p. 14181-14185.
Argintaru O.A. et al.
2013, 52(51), p. 13656-13660.
Docket # Z6435
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Chemical Processes and Synthesis
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