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Ionizable lipid nanoparticles (LNPs) are an emerging method to deliver mRNA to cells in vivo. However, targeting LNPs to deliver their mRNA cargo to a specific tissue of interest following intravenous injection has hampered their utility.
Using a mini-library of b-mRNA LNPs, a pool of different b-mRNA LNP formulations can be simultaneously administered intravenously into mice as a single pool. The relative delivery efficacy of different b-mRNA LNPs to any target organ can then be determined via deep sequencing to determine the relative abundance of all b-mRNA LNPs in the organ of interest.