Spine TK: Deep Learning AI Toolkit for Spine Health Assessment

Fast quantification of spine fractures, curvature, vertebral deformities, vertebral texture, vertebral strength, bone density, and intervertebral disk measurements using CT, MR, DXA, PET, or X-ray images for evaluation of spine health and surgery planning.

Problem:

Bone mass and quality deficiencies are the leading cause of bone disease in the United States. Vertebral fractures attributed to poor bone quality (e.g., osteoporosis) are a major medical concern that may require surgical treatment and often result in physical disability. Unfortunately, use of medical imaging leads to detection of only one third of vertebral deformities/fractures as vertebral measurements are generally obtained by radiologists and orthopaedic surgeons by manual annotation of vertebrae. Patients undergoing spine surgeries or those at risk for osteoporosis could benefit from state-of-the-art spine health analysis.

Technology Overview:

The invention is an automated, neural network used for analysis of the vertebral bodies on spine MR, CT, PET, or X-ray imaging. This approach allows to determine vertebra-by-vertebra deformity including scoliosis and lordosis as well as to monitor changes in bone strength, density, and structures over time. It allows for simultaneous intervertebral disk measurements and can be used for the diagnosis of disk degeneration and spine fusions. The invention presents an opportunity for early diagnosis of vertebral health which would permit early interventions, could be useful for spine surgery planning, intra-operative surgical decision making, and robotic surgical guidance.

Advantages:

  • Saves time for radiologists and orthopaedic surgeons
  • Avoids subjectivity introduced by manual measurements

Basic overview of the method. 

Stage of Development:   

  • The AI model is fully trained, tested, and validated using a large number of real-world spine images of patients. Fully functional software had been developed.

Intellectual Property:

Desired Partnerships: 

  • License
  • Co-development 
Patent Information:

Contact

Linara Axanova

Interim Director, PSOM Licensing Group
University of Pennsylvania

INVENTORS

Keywords

Docket # 21-9508