Available Technologies

Browse Penn-owned technologies available for licensing.


Search Results - brian litt

7 Results Sort By:
Electrodes for long term in-vivo implantation and in-vitro use
Problem: Implantable devices for use in the body of a subject, such as neural prosthetic systems, have had limited success due to the challenges presented by the environment the devices are exposed to. Long-term interaction with the implantable device and the body takes a toll on these implantable devices. Impedance degradation, scar tissue formation,...
Published: 3/23/2020   |   Inventor(s): Brian Litt
Category(s): Medical Devices
High spatial and temporal resolution mapping of brain activity using flexible multiplexed electrode arrays with long term stability and safety
Flexible foldable actively multiplexed high density electrode array for mapping brain activity in-vivo Problem: Electrode arrays for recording and stimulating the brain are used throughout clinical medicine and basic neuroscience research, but are unable to sample large areas of the brain while maintaining high spatial resolution because of the...
Published: 3/19/2020   |   Inventor(s): Brian Litt
Keywords(s): Neurodegenerative Diseases
Category(s): Diagnostics, Medical Devices
Classifying high-frequency oscillations in physiological recordings
Method for automatic and unsupervised classification of high-frequency oscillations in physiological recordings. Problem: Automatic detection and classification of high frequency oscillations (HFO) data for use in clinical diagnosis and therapy has been limited. Currently, researchers visually inspect for high frequency oscillations. Solution:...
Published: 3/18/2020   |   Inventor(s): Brian Litt
Keywords(s): Bioengineering, Neurodegenerative Diseases
Category(s): IT & Communication & Networking, Research Tools & Reagents, Imaging, Medical Devices
Measuring and manipulating neuronal signals using implantable electronic microsensor arrays
Problem: Most current implantable brain devices stimulate large regions of the brain without sensing. These devices are not able to access the fine multi-scale architecture comprising brain function and do not interact with the brain’s capacity for self-reorganization and repair. Solution: An implantable electronic micro-sensor array on...
Published: 3/11/2020   |   Inventor(s): Brian Litt
Keywords(s): Neurodegenerative Diseases
Category(s): Diagnostics, Medical Devices
2D metal carbides and nitrides (MXenes) electrodes
Problem: Current implantable devices for recording and stimulating electrical activity in the body are fabricated with metal based components. The metal components pose issues for long term implantation and functionality, including scarring, inflammation, degradation and fatigue. Furthermore, the physical properties of metals are typically inadequate...
Published: 2/6/2020   |   Inventor(s): Flavia Vitale, Brian Litt
Category(s): Diagnostics, Medical Devices
Transparent graphene electrodes to image and monitor biological tissues
Transparent electrode arrays for visualization, simultaneous imaging, and electrophysiology Problem: Calcium imaging is a versatile tool capable of resolving single neurons and their connectivity with single-cell spatial resolution in the brain. Unfortunately, its coarse temporal resolution limits its ability to detect neural activity with a...
Published: 1/23/2020   |   Inventor(s): Brian Litt
Category(s): Materials, Diagnostics
Implantable device to treat epilepsy
Diagnostic and preventative implantable device with computer-brain interface for treatment of epilepsy. Problem: One percent of the world’s population suffers from epilepsy. Aside from seizures’ debilitating effects, patients are confined by their unpredictability. Prevention is one way to decrease seizures, but measures usually focus...
Published: 11/27/2018   |   Inventor(s): Brian Litt
Keywords(s): Bioengineering
Category(s): Diagnostics, Therapeutics & Vaccines, Materials, Medical Devices, IT & Communication & Networking