Search Results - drug+target

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Silencing of PRLΔE1 expression: a gene-agnostic treatment for retinal degenerations

Viral vector-mediated gene silencing of a novel short retinal isoform of Prolactin promotes photoreceptor survival.

Published: 3/12/2024
Inventor(s):
William Beltran, Raghavi Sudharsan
Keywords(s):
Drug Target, Gene Therapy, Genetic Disorders, Neurodegenerative Diseases, Ophthalmology, Orphan Disease
Category(s):
Technology Classifications > Therapeutics

Topical LSD1 Inhibition for Treating Skin Diseases

Topical LSD1 inhibition can treat skin diseases that include cutaneous squamous cell carcinoma (cSCC), actinic keratoses, and viral warts.

Published: 2/12/2024
Inventor(s):
Brian Capell, Napasorn (Nina) Kuprasertkul
Keywords(s):
Dermatology, Drug Delivery, Drug Target, Immunoncology, Oncology
Category(s):
Technology Classifications > Therapeutics

Accurate Blood Biomarkers for Early Diagnosis of Synovial Joint Disease in the Mucopolysaccharidoses

Ten candidate serum and synovial protein levels provide early indication of joint impairment in lysosomal storage disorders.

Published: 1/11/2024
Inventor(s):
Lachlan Smith, Chenghao Zhang
Keywords(s):
Bioengineering, Cell Therapy, Drug Target, Genetic Disorders, Inflammation, Orthopedics, Regenerative Medicine
Category(s):
Technology Classifications > Diagnostics, Technology Classifications > Testing & Measurement

Library of Novel Anesthetic (Propofol) Antagonists

A library of chemical compounds that reverse the anesthetic effects of propofol.

Published: 2/2/2024
Inventor(s):
Elizabeth White, Roderic Eckenhoff, William Dailey, Kellie Woll, Andrew McKinstry-Wu, Victoria Bedell
Keywords(s):
Drug Target, Surgery
Category(s):
Technology Classifications > Chemical Processes and Synthesis

Modified Lipid Nanoparticle Formulations with Improved Therapeutic Delivery to the Bone Microenvironment In-vivo

A library of bi-phosphonate ionizable lipids and LNP formulations to facilitate mRNA delivery to the bone microenvironment. 

Published: 2/7/2024
Inventor(s):
Michael Mitchell, Lulu Xue
Keywords(s):
Drug Delivery, Drug Target, Nanotechnology, Orthopedics, Platform Technology, Regenerative Medicine
Category(s):
Technology Classifications > Vaccines, Technology Classifications > Therapeutics, Technology Classifications > Research Tools & Reagents

Up-regulators of utrophin expression for the treatment of muscular dystrophy

Small molecules targeting utrophin mRNA untranslated regions overcome post-transcriptional repression

Published: 2/12/2024
Inventor(s):
Tejvir Khurana, Donna Huryn
Keywords(s):
Drug Target, Genetic Disorders
Category(s):
Technology Classifications > Therapeutics

Therapeutic to Mitigate Epilepsy and Autism Development in Newborn Seizure Patients

Neonatal brains are at high risk for seizures due to heightened electrical activity corresponding to neural development. Though anticonvulsant drugs exist to treat the seizures immediately, certain synaptic receptors (CP-AMPARs) become highly expressed, increasing the likelihood of developing epilepsy and autism-spectrum disorders. The inventors propose using CP-AMPAR blockers such as IEM-1460 to curb CP-AMPAR activity and prevent development of epilepsy and other neurological disorders. 

Published: 1/12/2024
Inventor(s):
Frances Jensen
Keywords(s):
Drug Target, Neurology
Category(s):
Technology Classifications > Therapeutics

The g3mclass Software for Multiclass Disease Diagnosis and Reporting.

Diagnostic software to stratify patients on biomarkers and therapeutic targets.

Published: 2/12/2024
Inventor(s):
Marina Guvakova
Keywords(s):
Artificial Intelligence (AI) & Machine Learning, Data Science, Drug Target, Immunoncology, Men's Health, Neurology, Obesity, Metabolic Disease and Diabetes, Oncology, Software, Surgery, Women's Health
Category(s):
Technology Classifications > Animal Health, Technology Classifications > Diagnostics, Technology Classifications > Therapeutics, Technology Classifications > Testing & Measurement