Search Results - drug+target

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Pharmacological Treatment for Sleep Disorders Improving Sleep Quality & Architecture

Targeting Heat Shock Factor 1 (HSF1) via gene therapy or using pharmacological compounds targeting HSF1 (e.g. geranylgeranylacetone or macrocyclic peptides) can increase sleep stability, promote deeper sleep, reduce sleep fragmentation, and improve recovery from sleep loss.

Published: 4/16/2026
Inventor(s):
Akhilesh Basi Reddy, Shintaro Yamazaki
Keywords(s):
Aging, Drug Target, Gene Therapy, Neurodegenerative Diseases, Protein/Peptide (Non-Antibody), Small Molecule, Women's Health
Category(s):
Technology Classifications > Therapeutics

Mechanically Tunable Engineered Heart Tissue Platform

Next-generation engineered heart tissue platform that enables precise tuning of mechanical properties of microenvironment to study the structure, development, and function of cultured cells or human-derived cardiac tissues.

Published: 1/30/2026
Inventor(s):
Kenneth Margulies, Benjamin Lee, Nesrine Bouhrira
Keywords(s):
Bioengineering, Cardiovascular, Drug Target, Platform Technology
Category(s):
Technology Classifications > Hardware & Components, Technology Classifications > Research Tools & Reagents, Technology Classifications > Testing & Measurement

Anticancer IgG Against Multiple Epitopes on Live Tumors Upon Disruption of ‘Self’ Signaling by CD47

A method to combine two or three monoclonal antibodies (mABs) into one treatment to successfully bind to multiple cancer cell surface epitopes and promote targeted degradation by phagocytosis.

Published: 12/15/2025
Inventor(s):
Dennis Discher, Jason Andrechak, Lawrence Dooling
Keywords(s):
Antibody, Bioengineering, Cell Therapy, Drug Target, Immunology, Immunoncology, Immunotherapy, Oncology, Platform Technology
Category(s):
Technology Classifications > Therapeutics

A Potent HIV Treatment with Low Toxicity

A small-molecule class that binds to HIV particles to improve immune response and block viral entry into cells.

Published: 11/11/2025
Inventor(s):
Amos Smith, Xuchen Zhao, Tyler Higgins, Andres Finzi, Shilei Ding, Daniel Lee, Marzena Pazgier, Dung Nguyen, William Tolbert
Keywords(s):
Drug Target, HIV/AIDS, Small Molecule, Soft Materials
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics

DNA Secondary Structure (G-quadruplex) Stabilizers Improve Muscle Repair in Acute Injuries, Exercise, and Aging

Essential stem cell maintenance genes, including Pax7, a transcription factor fundamental to preserving the high regenerative capacity of muscles, is induced via targeting DNA secondary structures.

Published: 8/5/2025
Inventor(s):
Foteini Mourkioti, Ji-Hyung Lee
Keywords(s):
Aging, Drug Target, Orthopedics, Regenerative Medicine, Small Molecule
Category(s):
Technology Classifications > Therapeutics

Adhesive Microparticle Formulation For Localized And Sustained Drug Delivery

A hairy, water-in-oil-in-water microemulsion for prolonged delivery of one or more active ingredients while adhering to target tissues.

Published: 10/3/2025
Inventor(s):
Daeyeon Lee, Minjun Oh, Jaehyun Kim, Li-Wei Chang, Robert Mauck, George Dodge, Hyun (Michel) Koo
Keywords(s):
Bioengineering, Dentistry, Drug Delivery, Drug Target
Category(s):
Technology Classifications > Materials

Silencing of PRLΔE1 expression: a gene-agnostic treatment for retinal degenerations

Viral vector-mediated gene silencing of a novel short retinal isoform of Prolactin promotes photoreceptor survival.

Published: 9/8/2025
Inventor(s):
William Beltran, Raghavi Sudharsan
Keywords(s):
Drug Target, Gene Therapy, Genetic Disorders, Neurodegenerative Diseases, Ophthalmology, Orphan Disease
Category(s):
Technology Classifications > Therapeutics

Topical LSD1 Inhibition for Treating Skin Diseases

Topical LSD1 inhibition can treat skin diseases that include cutaneous squamous cell carcinoma (cSCC), actinic keratoses, and viral warts.

Published: 8/21/2025
Inventor(s):
Brian Capell, Napasorn (Nina) Kuprasertkul
Keywords(s):
Dermatology, Drug Delivery, Drug Target, Immunoncology, Oncology
Category(s):
Technology Classifications > Therapeutics

Accurate Blood Biomarkers for Early Diagnosis of Synovial Joint Disease in the Mucopolysaccharidoses

Ten candidate serum and synovial protein levels provide early indication of joint impairment in lysosomal storage disorders.

Published: 8/5/2025
Inventor(s):
Lachlan Smith, Chenghao Zhang
Keywords(s):
Bioengineering, Cell Therapy, Drug Target, Genetic Disorders, Inflammation, Orthopedics, Regenerative Medicine
Category(s):
Technology Classifications > Diagnostics, Technology Classifications > Testing & Measurement

Modified Lipid Nanoparticle Formulations with Improved Therapeutic Delivery to the Bone Microenvironment In-vivo

A library of bi-phosphonate ionizable lipids and LNP formulations to facilitate mRNA delivery to the bone microenvironment. 

Published: 11/26/2025
Inventor(s):
Michael Mitchell, Lulu Xue
Keywords(s):
Drug Delivery, Drug Target, Nanotechnology, Orthopedics, Platform Technology, Regenerative Medicine
Category(s):
Technology Classifications > Vaccines, Technology Classifications > Therapeutics, Technology Classifications > Research Tools & Reagents
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