Engineered Fanzor2 (Fz2) nucleases with enhanced genome editing activity in mammalian cells and demonstrated genome editing in mice.
A high throughput, model-guided tool that prioritizes candidate amino acid substitutions for protein optimization under sparse data conditions.
A quick and inexpensive method to detect cancer early by exponentially amplifying rare and scarce cancer mutations.
A flexible toolkit for human gene editing, activation, and repression that can be applied in orthogonally and in various disease models.
Microfluidic device for generation of large, precisely-defined, diverse lipid nanoparticle libraries for screening LNP formulations.
Simple, plug-and-play biodegradable lipids that form highly potent lipid nanoparticles (LNPs) for CRISPR mRNA delivery, outperforming benchmark gene-editing systems.
Technology allowing efficient formation, delivery, isolation, and enrichment of single-copy Human Artificial Chromosome (HAC) for use in research, plant production, gene and cell therapy and more.
Synergistic combination of mechanoporation and lipid nanoparticle (LNP) based transfection for an efficient, non-viral method of gene transfer to generate CAR-T cell therapies.
[%brief%]
Approaches and Design Techniques to Alleviate Coagulation-Related Acute Side Effects of Lung-Targeted Nanocarriers