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Search Results - haim bau

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A disposable self-heating cartridge for point-of-care molecular diagnostics
A water-activated, self-heating, instrument-free microfluidic diagnostic cartridge Problem: Many molecular diagnostic devices require elevated temperatures to carry out biochemical reactions, such as those needed for nucleic acid amplification, including loop-mediated isothermal amplification (LAMP). The temperature is typically regulated with...
Published: 3/19/2020   |   Inventor(s): Changchun Liu, Haim Bau
Keywords(s):  
Category(s): Diagnostics, Medical Devices, Research Tools & Reagents
A membrane-based, high-efficiency microfluidic debubbler for point-of-care devices
Problem: Microfluidic devices often suffer from unwanted bubbles inside a channel, resulting in obstructed fluidic paths, lower reaction efficiency, detection distortion, and interference with bead array-based assays. Existing active debubblers that use pneumatics or vacuum to trap and dissipate bubbles require an external vacuum source, preventing...
Published: 3/19/2020   |   Inventor(s): Haim Bau, Changchun Liu
Keywords(s):  
Category(s): Diagnostics, Medical Devices, Research Tools & Reagents
A flow cell for electron microscope imaging with multiple flow streams
Nanoaquarium: nanofluidic platform for in situ TEM imaging of fluid-mediated samples Problem: Many nanoscale phenomena occur in liquid media, including nanoparticle and colloidal formation, nanowire liquid phase growth, electrochemical deposition and etching for batteries, and biological interactions. Real-time, in situ transmission electron...
Published: 3/18/2020   |   Inventor(s): Haim Bau
Keywords(s):  
Category(s): Imaging, Research Tools & Reagents
Carbon-based nanopipettes for single cell injection
Multiplexed, nanoscale electrochemical sensor for analyte delivery and detection Technology Overview: The Bau Lab has developed carbon-based nanopipettes (CNPs) that allow for reliable single cell injection. These CNPs use an AC electrical impedance measurement to detect cell and nucleus penetration, which greatly improves upon standard pulled...
Published: 3/16/2020   |   Inventor(s): Haim Bau
Keywords(s): Nanotechnology
Category(s): Research Tools & Reagents, Materials
A portable, real-time enzymatic amplification reactor with dry storage of reagents
Point-of-care diagnostic system for nucleic acid-based analysis Technology Overview: The Bau Lab has developed a pre-loaded analysis module with reagents stored within a barrier material capable of liberating the reagents at a desired time upon exposure to activation conditions. Reagents are first prepared in dried form and encapsulated with a...
Published: 3/10/2020   |   Inventor(s): Haim Bau, Michael Mauk
Keywords(s):  
Category(s): Diagnostics, Medical Devices
A pouch-based cassette for bio-detection with timer-based actuator
Bio-detection cassette with automated actuator for self-contained immunoassay devices and lab-on-a-chip assays Technology Overview: The Bau Lab has developed a device that sequentially delivers multiple reagents into a microfluidics based lab-on-a-chip system. Protrusions on a rotating wheel sequentially press plastic balls onto flexible diaphragms,...
Published: 3/6/2020   |   Inventor(s): Haim Bau, Changchun Liu
Keywords(s):  
Category(s): Diagnostics, Medical Devices
A method for highly selective nucleic acid enrichment for sensitive detection of mutations in cancer and genectic conditions.
This technology increases the fraction of clinically relevant, rare mutant alleles (DNA and/or RNA) to enable high sensitivity detection with common downstream methods such as capped (XNA or PNA) PCR, ddPCR, and sequencing. Problem: Liquid biopsy is a simple, minimally invasive, rapidly developing diagnostic method to analyze cell-free nucleic...
Published: 2/7/2020   |   Inventor(s): Jinzhao Song, Haim Bau, Michael Mauk, Jorrit Hegge, John van der Oost
Keywords(s):  
Category(s): Diagnostics, Hardware & Circuits & Sensors, Medical Devices, Research Tools & Reagents, Veterinary & Animal Health
Method and microfluidic chip for two-stage multiplexed isothermal enzymatic amplification
On-chip two-step nucleic acid amplification for point-of-care and clinical molecular detection of multiple diseases and co-infections Problem: Polymerase chain reaction methods (PCR) for nucleic acid amplification have revolutionized molecular diagnostics and genetics research. Nested PCR relies on two successive runs of thermal cycling and two...
Published: 2/3/2020   |   Inventor(s): Haim Bau, Changchun Liu
Keywords(s):  
Category(s): Diagnostics, Medical Devices, Research Tools & Reagents
A reverse transcription loop-mediated isothermal amplification method to quantify multiple HIV subtypes
A rapid, quantitative point-of-care diagnostics method for viral load detection of HIV-1 clades A, B, C, D, and G Problem: HIV infection remains an international health crisis, where it is especially acute in sub-Saharan Africa, despite the development of antiretroviral therapy. High sensitivity, point-of-care clinical diagnostic tests for detecting...
Published: 1/28/2020   |   Inventor(s): Haim Bau, Changchun Liu, Frederic Bushman
Keywords(s):  
Category(s): Diagnostics, Research Tools & Reagents, Medical Devices
Nuclemeter: A yardstick for quantifying nucleic acids undergoing enzymatic amplification
or drug therapy efficacy, and identify the emergence of drug-resistant strains, particularly HIV. While real-time nucleic acid amplification and quantification methods, such as PCR, have revolutionized modern genetics and diagnostics, expensive specialized instrumentation and extensive sample preparation are needed, along with continuous monitoring...
Published: 1/23/2020   |   Inventor(s): Haim Bau, Changchun Liu, Michael Mauk
Keywords(s): Nanotechnology
Category(s): Diagnostics, Research Tools & Reagents
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