Available Technologies

Browse Penn-owned technologies available for licensing.

Search Results - haim+bau

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A homogenous self-heating, temperature-regulating composite material

A cost-effective homogenous, composite material provides sustained heat at a desired temperature for point-of-care diagnostics and other applications. Problem: Point-of-care (POC) diagnostic tests have the potential to greatly enhance patient care and accessibility by reducing the time and equipment necessary for testing. Many current POC tests require...

Published: 5/7/2021

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A disposable self-heating cartridge for point-of-care molecular diagnostics

A water-activated, self-heating, instrument-free microfluidic diagnostic cartridge Problem: Many molecular diagnostic devices require elevated temperatures to carry out biochemical reactions, such as those needed for nucleic acid amplification, including loop-mediated isothermal amplification (LAMP). The temperature is typically regulated with external...

Published: 3/19/2020

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A membrane-based, high-efficiency microfluidic debubbler for point-of-care devices

Problem: Microfluidic devices often suffer from unwanted bubbles inside a channel, resulting in obstructed fluidic paths, lower reaction efficiency, detection distortion, and interference with bead array-based assays. Existing active debubblers that use pneumatics or vacuum to trap and dissipate bubbles require an external vacuum source, preventing...

Published: 3/19/2020

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A flow cell for electron microscope imaging with multiple flow streams

Nanoaquarium: nanofluidic platform for in situ TEM imaging of fluid-mediated samples Problem: Many nanoscale phenomena occur in liquid media, including nanoparticle and colloidal formation, nanowire liquid phase growth, electrochemical deposition and etching for batteries, and biological interactions. Real-time, in situ transmission electron microscope...

Published: 3/18/2020

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Carbon-based nanopipettes for single cell injection

Multiplexed, nanoscale electrochemical sensor for analyte delivery and detection Technology Overview: The Bau Lab has developed carbon-based nanopipettes (CNPs) that allow for reliable single cell injection. These CNPs use an AC electrical impedance measurement to detect cell and nucleus penetration, which greatly improves upon standard pulled glass...

Published: 3/16/2020

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A pouch-based cassette for bio-detection with timer-based actuator

Bio-detection cassette with automated actuator for self-contained immunoassay devices and lab-on-a-chip assaysTechnology Overview: The Bau Lab has developed a device that sequentially delivers multiple reagents into a microfluidics based lab-on-a-chip system. Protrusions on a rotating wheel sequentially press plastic balls onto flexible diaphragms,...

Published: 3/6/2020

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A method for highly selective nucleic acid enrichment for sensitive detection of mutations in cancer and genectic conditions.

This technology increases the fraction of clinically relevant, rare mutant alleles (DNA and/or RNA) to enable high sensitivity detection with common downstream methods such as capped (XNA or PNA) PCR, ddPCR, and sequencing. Problem: Liquid biopsy is a simple, minimally invasive, rapidly developing diagnostic method to analyze cell-free nucleic...

Published: 2/7/2020

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Method and microfluidic chip for two-stage multiplexed isothermal enzymatic amplification

On-chip two-step nucleic acid amplification for point-of-care and clinical molecular detection of multiple diseases and co-infections Problem: Polymerase chain reaction methods (PCR) for nucleic acid amplification have revolutionized molecular diagnostics and genetics research. Nested PCR relies on two successive runs of thermal cycling and two...

Published: 2/3/2020

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A reverse transcription loop-mediated isothermal amplification method to quantify multiple HIV subtypes

A rapid, quantitative point-of-care diagnostics method for viral load detection of HIV-1 clades A, B, C, D, and G Problem: HIV infection remains an international health crisis, where it is especially acute in sub-Saharan Africa, despite the development of antiretroviral therapy. High sensitivity, point-of-care clinical diagnostic tests for detecting...

Published: 1/28/2020

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Nuclemeter: A yardstick for quantifying nucleic acids undergoing enzymatic amplification

Point-of-care, reaction-diffusion column-based, non-instrumented device for real-time visual measurement of viral load in resource-limited settings, in the clinic, and at home Problem: Quantification of viral load in patients is needed to assess disease progression, monitor drug therapy efficacy, and identify the emergence of drug-resistant strains,...

Published: 1/23/2020

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