Search Results - immunology

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Methods to convert anti-tumor autoantibodies into highly potent bispecific T-cell redirecting antibodies for advanced T-cell recruitment in cancer treatment

Conjugating anti-T cell targeting domains onto anti-tumor autoantibodies to convert them into highly specific T cell-redirecting antibodies capable of increasing immune cell recruitment to tumor tissue.

Published: 8/19/2026
Inventor(s):
Andrew Tsourkas, James Hui, Burcin Altun, Fabiana Zappala
Keywords(s):
Bioengineering, Cell Therapy, Drug Delivery, Immunology, Immunoncology, Immunotherapy, Oncology, Platform Technology
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics

Highly Selective, Bioengineered Cytokine Reduces Inflammation For Prevention Of Heart Failure After Heart Attack

Targeted delivery of an anti-inflammatory cytokine to prevent heart failure after myocardial infarction.

Published: 8/6/2026
Inventor(s):
Noor Momin, Emily Jacobs
Keywords(s):
Bioengineering, Cardiovascular, Drug Delivery, Drug Target, Immunology, Immunotherapy, Inflammation, Protein/Peptide (Non-Antibody), Pulmonary
Category(s):
Technology Classifications > Therapeutics

Small-Molecule Therapeutic for Stabilizing HIV-1 Envelope Proteins to Increase Immune Response

Small-molecule inhibitor that prolongs exposure of HIV-1 to broadly neutralizing antibodies to suppress viral entry and infection

Published: 8/6/2026
Inventor(s):
Amos Smith, Althea Lang, Joseph Sodroski
Keywords(s):
Drug Target, HIV/AIDS, Immunology, Infectious Disease
Category(s):
Technology Classifications > Therapeutics, Technology Classifications > Chemical Processes and Synthesis

Increasing Efficiency of Anti-Tumor Immune Checkpoint Blockade Therapy by Manipulating Tumor-Associated Macrophages

A method to manipulate tumor-associated macrophages by targeting the mitochondrial electron transport chain, improving the efficacy of immune checkpoint blockade cancer therapies.

Published: 8/6/2026
Inventor(s):
Jorge Henao-Mejia, Megan Clark
Keywords(s):
Drug Target, Immunology, Oncology
Category(s):
Technology Classifications > Therapeutics

Precise, Efficient Delivery of mRNA Medicine to the Placenta

Using tiny lipid nanoparticles (LNPs) to improve mRNA medicine delivery and uptake in the placenta for healthier pregnancies

Published: 8/6/2026
Inventor(s):
Michael Mitchell, Hannah Safford, Kelsey Swingle, Hannah Geisler
Keywords(s):
Bioengineering, Drug Delivery, Gene Therapy, Immunology, Immunotherapy, Women's Health
Category(s):
Technology Classifications > Therapeutics

Device For Rapid, Tunable, And Scalable Generation Of Lipid Nanoparticle Formulations

Microfluidic device for generation of large, precisely-defined, diverse lipid nanoparticle libraries for screening LNP formulations.

Published: 8/6/2026
Inventor(s):
Michael Mitchell, David Issadore, Andrew Hanna
Keywords(s):
Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Immunology, Immunotherapy, Microfluidics, Nanotechnology
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Hardware & Components, Technology Classifications > Robotics

Methods for Treating, Ameliorating, and Preventing Nephropathy/Nephritis

Method for protecting against nephropathy/nephritis through topical administration of a vitamin D3 analog, producing systemic therapeutic effects potentially beneficial in protein-losing nephropathy, lupus nephritis, diabetic nephropathy, focal segmental glomerulosclerosis (FSGS), and genetic nephropathies.

Published: 8/6/2026
Inventor(s):
Taku Kambayashi, Yuichi Yokoyama
Keywords(s):
Immunology, Nephrology and Urology
Category(s):
Technology Classifications > Therapeutics

Anticancer IgG Against Multiple Epitopes on Live Tumors Upon Disruption of ‘Self’ Signaling by CD47

A method to combine two or three monoclonal antibodies (mABs) into one treatment to successfully bind to multiple cancer cell surface epitopes and promote targeted degradation by phagocytosis.

Published: 8/6/2026
Inventor(s):
Dennis Discher, Jason Andrechak, Lawrence Dooling
Keywords(s):
Antibody, Bioengineering, Cell Therapy, Drug Target, Immunology, Immunoncology, Immunotherapy, Oncology, Platform Technology
Category(s):
Technology Classifications > Therapeutics

T Cells Targeting Misformed Proteins to Treat Neurodegenerative and Muscular Diseases

Antigen-specific immunotherapy with engineered cytotoxic T cells targeting misformed proteins to treat neurodegenerative and muscular diseases.

Published: 8/6/2026
Inventor(s):
Ning (Jenny) Jiang, Shahab (Shawn) Chizari
Keywords(s):
Bioengineering, Cell Therapy, Immunology, Immunotherapy, Inflammation, Neurodegenerative Diseases
Category(s):
Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics

LNP + Squeeze: Enhancing Chimeric Antigen Receptor T-Cell Generation via Mechanoporation and Lipid Nanoparticles

Synergistic combination of mechanoporation and lipid nanoparticle (LNP) based transfection for an efficient, non-viral method of gene transfer to generate CAR-T cell therapies.

Published: 8/6/2026
Inventor(s):
Jina Ko, Jianhua Lim
Keywords(s):
Bioengineering, Cell Therapy, Gene Editing, Immunology, Immunoncology, Microfluidics, Nanotechnology
Category(s):
Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics, Technology Classifications > Chemical Processes and Synthesis
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