Dental implant that inhibits plaque accumulation and gingival tissue inflammation by photobiomodulation therapy delivered by embedded light-emitting diodes (LEDs) powered by electricity generated from the patient’s own oral motion.Problem: More than half of adults will lose one or more teeth in their lifetime. When a patient loses a tooth the...

Problem: Sepsis, an overwhelming and life-threatening response to infection, is the most common cause of death in US hospitals. Sepsis is associated with a mortality rate of 25–30% and mortality due to septic shock is 50–85%. Rapid diagnosis and intervention in sepsis are essential given an increased mortality rate of 8% for every hour...

A portable point-of-care device for rapid and sensitive detection of acute SARS-CoV-2 infections. Problem: The COVID-19 pandemic has infected over 40 million people worldwide as of mid-October 2020, causing more than 1 million deaths. Up to 50-80% of transmissions occur from asymptomatic patients. Current tests can have a turnaround time of hours...

Novel derivatives of oleic acid effectively inhibiting ferroptosis that could be used for treatment of Friedreich Ataxia, neurodegenerative diseases, and neuropsychiatric diseases. Problem: Ferroptosis is a non-apoptotic form of cell death characterized by the iron-dependent accumulation of toxic lipid-reactive oxygen species. Ferroptosis has been...

A library of ionizable lipid nanoparticles (LNPs) was screened for ability to deliver mRNA to T-cells, leading to an optimized LNP formulation for delivery of mRNA to T-cells. This thereby enhances the ability to generate transient chimeric antigen receptor (CAR)-expressing T-cells for cancer immunotherapy.Problem: Chimeric antigen receptor (CAR) T-cells...

Interdependence of oncogenic and epigenetic mechanisms in T-cell lymphoma. Technology Overview: Anaplastic large cell lymphoma (ALCL) is a highly malignant type of Non-Hodgkin’s T cell lymphoma in which chromosomal translocation leads to the expression of a fusion oncoprotein Tyrosine Kinase - Nucleophosmin/Anaplastic Lymphoma Kinase or NPM/ALK. Dr....

The fully human CAR targets mesothelin, a surface protein overexpressed in several cancer types. P4, a human antibody fragment that binds human mesothelin with high specificity, is fused to T cell signaling domains such as 28z. The T cells engineered to express this CAR are shown to shrink tumors in a mouse model bearing human ovarian tumors overexpressing...

CXCR6 is a chemokine receptor expressed by leukocytes and other cells, and is believed to play a role in cancer metastasis, gut mucosal integrity, autoimmunity, diabetes and other inflammatory disorders. It is also used by SIV as a co-receptor for target cell entry. Technology Overview: Current commercially available monoclonal antibodies that...

Technology Overview: Maintenance of tolerance to self-antigens is essential for the prevention of autoimmunity. This process is known to involve specific regulatory T cells (Treg) and the expression of the forkhead family transcription factor, FOXP3. FOXP3 is a “sufficient” regulator of the development and function of peripheral Treg...