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Gum-health promoting smart dental implant system

Dental implant that inhibits plaque accumulation and gingival tissue inflammation by photobiomodulation therapy delivered by embedded light-emitting diodes (LEDs) powered by electricity generated from the patient’s own oral motion. Problem: More than half of adults will lose one or more teeth in their lifetime. When a patient loses a tooth the...

Published: 2/9/2021

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Rapid pathogen diagnostic through amplification of red blood cell-associated DNA

Problem: Sepsis, an overwhelming and life-threatening response to infection, is the most common cause of death in US hospitals. Sepsis is associated with a mortality rate of 25–30% and mortality due to septic shock is 50–85%. Rapid diagnosis and intervention in sepsis are essential given an increased mortality rate of 8% for every hour...

Published: 11/24/2020

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Rapid and ultrasensitive SARS-CoV-2 antigen detection for acute COVID-19 screening in community settings

rss.brief>A portable point-of-care device for rapid and sensitive detection of acute SARS-CoV-2 infections. Problem: The COVID-19 pandemic has infected over 40 million people worldwide as of mid-October 2020, causing more than 1 million deaths. Up to 50-80% of transmissions occur from asymptomatic patients. Current tests can have a turnaround time...

Published: 11/11/2020

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Novel inhibitors of ferroptosis

Novel derivatives of oleic acid effectively inhibiting ferroptosis that could be used for treatment of Friedreich Ataxia, neurodegenerative diseases, and neuropsychiatric diseases. Problem: Ferroptosis is a non-apoptotic form of cell death characterized by the iron-dependent accumulation of toxic lipid-reactive oxygen species. Ferroptosis has been...

Published: 10/16/2020

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Lipid nanoparticle-based mRNA delivery for CAR T-cell engineering

A library of ionizable lipid nanoparticles (LNPs) was screened for ability to deliver mRNA to T-cells, leading to an optimized LNP formulation for delivery of mRNA to T-cells. This thereby enhances the ability to generate transient chimeric antigen receptor (CAR)-expressing T-cells for cancer immunotherapy. Problem: Chimeric antigen receptor (CAR)...

Published: 5/4/2020

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Therapeutic targets for T-cell lymphomas and other types of cancer

Interdependence of oncogenic and epigenetic mechanisms in T-cell lymphoma. Technology Overview: Anaplastic large cell lymphoma (ALCL) is a highly malignant type of Non-Hodgkin’s T cell lymphoma in which chromosomal translocation leads to the expression of a fusion oncoprotein Tyrosine Kinase - Nucleophosmin/Anaplastic Lymphoma Kinase or NPM/ALK. Dr....

Published: 3/20/2020

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Fully human anti-mesothelin CAR with low immunogenicity for in vivo persistence of anti-tumor engineered T cells

The fully human CAR targets mesothelin, a surface protein overexpressed in several cancer types. P4, a human antibody fragment that binds human mesothelin with high specificity, is fused to T cell signaling domains such as 28z. The T cells engineered to express this CAR are shown to shrink tumors in a mouse model bearing human ovarian tumors overexpressing...

Published: 1/29/2020

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Monoclonal antibody to CXCR6

CXCR6 is a chemokine receptor expressed by leukocytes and other cells, and is believed to play a role in cancer metastasis, gut mucosal integrity, autoimmunity, diabetes and other inflammatory disorders. It is also used by SIV as a co-receptor for target cell entry. Technology Overview: Current commercially available monoclonal antibodies that react...

Published: 1/28/2020

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A method to identify modulators for regulatory T cell functions

Technology Overview: Maintenance of tolerance to self-antigens is essential for the prevention of autoimmunity. This process is known to involve specific regulatory T cells (Treg) and the expression of the forkhead family transcription factor, FOXP3.FOXP3 is a “sufficient” regulator of the development and function of peripheral Treg cells,...

Published: 8/10/2017

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