Search Results - neurodegenerative+diseases

An All-In-One “Swiss Army Knife” Tool To Edit Genes And Regulate Their Expression Without Off-Target Effects And Toxicity

A flexible toolkit for human gene editing, activation, and repression that can be applied in orthogonally and in various disease models.

Published: 5/5/2026

Pharmacological Treatment for Sleep Disorders Improving Sleep Quality & Architecture

Targeting Heat Shock Factor 1 (HSF1) via gene therapy or using pharmacological compounds targeting HSF1 (e.g. geranylgeranylacetone or macrocyclic peptides) can increase sleep stability, promote deeper sleep, reduce sleep fragmentation, and improve recovery from sleep loss.

Published: 4/16/2026

Inventor(s):

Akhilesh Basi Reddy, Shintaro Yamazaki

Keywords(s):

Aging, Drug Target, Gene Therapy, Neurodegenerative Diseases, Protein/Peptide (Non-Antibody), Small Molecule, Women's Health

Category(s):

Technology Classifications > Therapeutics

An Accessible and Automated Device to Diagnose Nerve and Muscle Disorders

A device consisting of electrode patches, a control box, and software for automated nerve conduction studies.

Published: 4/8/2026

Inventor(s):

Josh Baxter, Flavia Vitale, Margaret (Maggie) Wagner, Quinn Tate

Keywords(s):

Artificial Intelligence (AI) & Machine Learning, Bioengineering, Neurodegenerative Diseases, Neurology, Orthopedics, Software

Category(s):

Technology Classifications > Hardware & Components, Technology Classifications > Diagnostics, Technology Classifications > Medical Devices, Technology Classifications > Testing & Measurement

T Cells Targeting Misformed Proteins to Treat Neurodegenerative and Muscular Diseases

Antigen-specific immunotherapy with engineered cytotoxic T cells targeting misformed proteins to treat neurodegenerative and muscular diseases.

Published: 11/11/2025

Inventor(s):

Ning Jenny Jiang, Shahab Chizari

Keywords(s):

Bioengineering, Cell Therapy, Immunology, Immunotherapy, Inflammation, Neurodegenerative Diseases

Category(s):

Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics

Intranasally-Delivered Therapy for Treatment of Amyotrophic Lateral Sclerosis

Intranasal delivery of dantrolene nanoparticles can improve motor neuron function, muscle strength, and movement coordination and can offer therapeutic benefits for treatment of Amyotrophic Lateral Sclerosis (ASL).

Published: 9/30/2025

Inventor(s):

Huafeng Wei

Keywords(s):

Genetic Disorders, Inflammation, Neurodegenerative Diseases, Neurology, Pulmonary, Small Molecule

Category(s):

Technology Classifications > Therapeutics

Intranasally-Delivered Therapy For The Treatment Of Depression And Dementia

Intranasal nasal dantrolene nanoparticles alone, or in combination with lithium, can provide protection against depression and dementia with minimal or no side effects.

Published: 8/1/2025

Inventor(s):

Huafeng Wei

Keywords(s):

Aging, Immunology, Immunoncology, Infectious Disease, Inflammation, Neurodegenerative Diseases

Category(s):

Technology Classifications > Therapeutics

Intranasal Dantrolene Nanoparticle Use For Treatment Of Alzheimer's Disease

Intranasal delivering of dantrolene nanoparticles could potentially be used to inhibit memory loss and reduce amyloid plaques in patients with Alzheimer's disease.

Published: 8/1/2025

Inventor(s):

Huafeng Wei, Qing Cheng Meng, Ge Liang, Maryellen Eckenhoff

Keywords(s):

Aging, COVID-19, Nanotechnology, Neurodegenerative Diseases

Category(s):

Technology Classifications > Animal Health, Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Food Science and Nutrition, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics

Machine-Learning Foundation Model For The Early Detection Of Neurodegenerative Diseases

A machine learning technique that identifies biomarkers from neuroimaging data, allowing for identification and treatment of populations vulnerable to neurodegenerative diseases.