Available Technologies

Browse Penn-owned technologies available for licensing.

Search Results - neurodegenerative+diseases

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Site-blocking oligos (SBO) upregulate utrophin for treatment of Duchenne Muscular Dystrophy (DMD

Synthetic oligonucleotides blocking natural degradation of utrophin to treat muscular dystrophy. Problem: Duchenne Muscular Dystrophy (DMD) is a severe form of muscular dystrophy affecting males. A genetic mutation causes decreased production of dystrophin, a critical protein connecting cells to surrounding tissue. This leads to improper muscle...

Published: 10/27/2022

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A wireless implantable tactile sensor for the fingers of a paralyzed limb

An implantable sensor paired with a wireless wrist watch that relays tactile information from a paralyzed hand to the user for guiding upper extremity movements. Problem: More than 5.4 million people in the United States suffer from paralysis, which hinders their ability to perform basic activities for daily living. Individuals with upper extremity...

Published: 10/31/2022

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Novel pyrimidine derivatives to treat Alzheimer’s Disease

Brain penetrating compounds as promising therapeutics for treatment of neurodegenerative disorders. Problem: An estimated 6.2 million Americans live with Alzheimer’s Disease (AD), and this number is projected to reach over 13 million by 2050 with societal costs expected to rise to $1.1 trillion. A key feature of AD-affected brain tissue is the...

Published: 10/30/2021

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Novel inhibitors of ferroptosis

Novel derivatives of oleic acid effectively inhibiting ferroptosis that could be used for treatment of Friedreich Ataxia, neurodegenerative diseases, and neuropsychiatric diseases. Problem: Ferroptosis is a non-apoptotic form of cell death characterized by the iron-dependent accumulation of toxic lipid-reactive oxygen species. Ferroptosis has been...

Published: 9/13/2022

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Therapeutic antibodies against pathological tau proteins for the treatment of Alzheimer’s Disease (AD)

Two novel monoclonal antibodies were discovered that target pathological conformations of the tau protein. The antibodies were shown in vitro and in vivo to inhibit the spread of pathological tau protein aggregates, which is one of the defining characteristics of AD. Problem: More than 5 million Americans are living with Alzheimer’s disease...

Published: 10/30/2021

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Drug discovery and target identification platform technology using random shRNA-expressing library

shRNA library of 3 million sequences for identification of small-RNA therapeutic candidates, new targets and pathways, as well as conventional chemical-compound drugs in cell-culture disease models. Problem: ShRNA Drug Discovery: RNA interference (RNAi) using short hairpin RNA (shRNA) is commonly used to inhibit gene expression. shRNA-expressing...

Published: 9/12/2022

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High spatial and temporal resolution mapping of brain activity using flexible multiplexed electrode arrays with long term stability and safety

Flexible foldable actively multiplexed high density electrode array for mapping brain activity in-vivo Problem: Electrode arrays for recording and stimulating the brain are used throughout clinical medicine and basic neuroscience research, but are unable to sample large areas of the brain while maintaining high spatial resolution because of the need...

Published: 10/27/2022

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Classifying high-frequency oscillations in physiological recordings

Method for automatic and unsupervised classification of high-frequency oscillations in physiological recordings. Problem: Automatic detection and classification of high frequency oscillations (HFO) data for use in clinical diagnosis and therapy has been limited. Currently, researchers visually inspect for high frequency oscillations. Solution:...

Published: 10/27/2022

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Novel compounds for treatment for Friedreich Ataxia

New compounds identified through high throughput screening which improve mitochondrial function of Friedreich ataxia cells. Technology Overview: Friedreich ataxia (FA) is an autosomal recessive, inherited neuro- and cardio-degenerative disorder characterized by progressive ataxia of all four limbs, skeletal deformities, and hypertrophic cardiomyopathy....

Published: 9/12/2022

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Measuring and manipulating neuronal signals using implantable electronic microsensor arrays

Problem: Most current implantable brain devices stimulate large regions of the brain without sensing. These devices are not able to access the fine multi-scale architecture comprising brain function and do not interact with the brain’s capacity for self-reorganization and repair. Solution: An implantable electronic micro-sensor array on...

Published: 10/27/2022

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