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Search Results - neurodegenerative diseases

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Drug discovery and target identification platform technology using random shRNA-expressing library
shRNA library of 3 million sequences for identification of small-RNA therapeutic candidates, new targets and pathways, as well as conventional chemical-compound drugs in cell-culture disease models. Problem: ShRNA Drug Discovery: RNA interference (RNAi) using short hairpin RNA (shRNA) is commonly used to inhibit gene expression. shRNA-expressing...
Published: 3/19/2020   |   Inventor(s): Robert Wilson
Keywords(s): Neurodegenerative Diseases
Category(s): Diagnostics, Therapeutics & Vaccines, Research Tools & Reagents
High spatial and temporal resolution mapping of brain activity using flexible multiplexed electrode arrays with long term stability and safety
Flexible foldable actively multiplexed high density electrode array for mapping brain activity in-vivo Problem: Electrode arrays for recording and stimulating the brain are used throughout clinical medicine and basic neuroscience research, but are unable to sample large areas of the brain while maintaining high spatial resolution because of the...
Published: 3/19/2020   |   Inventor(s): Brian Litt
Keywords(s): Neurodegenerative Diseases
Category(s): Diagnostics, Medical Devices
Classifying high-frequency oscillations in physiological recordings
Method for automatic and unsupervised classification of high-frequency oscillations in physiological recordings. Problem: Automatic detection and classification of high frequency oscillations (HFO) data for use in clinical diagnosis and therapy has been limited. Currently, researchers visually inspect for high frequency oscillations. Solution:...
Published: 3/18/2020   |   Inventor(s): Brian Litt
Keywords(s): Bioengineering, Neurodegenerative Diseases
Category(s): IT & Communication & Networking, Research Tools & Reagents, Imaging, Medical Devices
Novel compounds for treatment for Friedreich Ataxia
New compounds identified through high throughput screening which improve mitochondrial function of Friedreich ataxia cells. Technology Overview: Friedreich ataxia (FA) is an autosomal recessive, inherited neuro- and cardio-degenerative disorder characterized by progressive ataxia of all four limbs, skeletal deformities, and hypertrophic cardiomyopathy....
Published: 3/16/2020   |   Inventor(s): Robert Wilson
Keywords(s): Neurodegenerative Diseases, Orphan Disease
Category(s): Therapeutics & Vaccines
Measuring and manipulating neuronal signals using implantable electronic microsensor arrays
Problem: Most current implantable brain devices stimulate large regions of the brain without sensing. These devices are not able to access the fine multi-scale architecture comprising brain function and do not interact with the brain’s capacity for self-reorganization and repair. Solution: An implantable electronic micro-sensor array on...
Published: 3/11/2020   |   Inventor(s): Brian Litt
Keywords(s): Neurodegenerative Diseases
Category(s): Diagnostics, Medical Devices
Development of impulse control disorders questionnaire for use in Parkinson’s disease and related disorders
o a potential side-effect of several classes of medication, particularly those targeting the dopamine system (i.e., dopamine agonists, levodopa and amantadine). Therefore, tools are needed to establish the existence or development of ICDs in at risk individuals, and to monitor changes in the severity of these behaviors. Solution: A questionnaire...
Published: 3/11/2020   |   Inventor(s): Daniel Weintraub
Keywords(s): Neurodegenerative Diseases
Category(s): Diagnostics
A New Approach to Treat Neurodegenerative Diseases
Technology Overview: Aberrant protein folding is severely problematic and manifests in numerous disorders, including amyotrophic lateral sclerosis (ALS), Parkinson disease (PD), Huntington disease (HD), and Alzheimer disease (AD). Patients with each of these disorders are characterized by the accumulation of mislocalized protein deposits. Treatments...
Published: 1/23/2020   |   Inventor(s): James Shorter, Meredith Jackrel
Keywords(s): Neurodegenerative Diseases
Category(s): Therapeutics & Vaccines