The base editing of phenylalanine hydroxylase enzyme in the liver to restore phenylalanine metabolism and prevent neurotoxic effects.
A single-use device which assists in stereotactic catheter placement into the cerebral ventricles and draining of cerebral spinal fluid (CSF)
Rapid, low-cost, and scalable production of comfortable electrode arrays suitable for measuring biosignals
A model to estimate the change in photoreceptor outer segment length that occurs upon light stimulation – a biomarker of cone function in the retina.
A method of treating Fragile X syndrome by correcting the abnormal DNA clusters causing the characteristic symptoms.
PennSorter is a specialized "spike-sorting" software designed to facilitate the precise assignment of electrical signals to cells with enhanced accuracy and efficiency.
Small molecule therapeutics that aid in clearing abnormal protein deposits observed in neurodegenerative diseases.
A nuclear magnetic resonance (NMR) based enzyme-detection system comprising xenon (129Xe) biosensors complexed with an enzyme-specific peptide substrate.
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Compounds are designed to detect and characterize specific RNAs in a cell or sub-cellular compartment using light activation.