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Anticancer IgG Against Multiple Epitopes on Live Tumors Upon Disruption of ‘Self’ Signaling by CD47

A method to combine two or three monoclonal antibodies (mABs) into one treatment to successfully bind to multiple cancer cell surface epitopes and promote targeted degradation by phagocytosis.

Published: 12/15/2025
Inventor(s):
Dennis Discher, Jason Andrechak, Lawrence Dooling
Keywords(s):
Antibody, Bioengineering, Cell Therapy, Drug Target, Immunology, Immunoncology, Immunotherapy, Oncology, Platform Technology
Category(s):
Technology Classifications > Therapeutics

Commercially Scalable Quantum Internet Architecture

A hybrid photonic system that enables quantum networking to scale across existing fiber infrastructure.

Published: 12/15/2025
Inventor(s):
Liang Feng, Yichi Zhang, Robert Broberg, Jonathan Smith
Keywords(s):
Electronic Materials, Optics & Photonics 
Category(s):
Technology Classifications > Computer Information Systems, Technology Classifications > Hardware & Components, Technology Classifications > Materials

DREAMER: Single-Scan, Multi-Contrast 3D Magnetic Resonance Imaging of Solid and Soft Tissue

A rapid, radiation-free magnetic resonance imaging (MRI) method that simultaneously captures bone-selective (pseudo-CT) bone images and high-resolution T1- and T2-weighted soft-tissue images in a single, self-registered 3D scan.

Published: 12/9/2025
Inventor(s):
Chamith Rajapakse, Brian-Tinh Duc Vu, Felix Wehrli, Nada Kamona
Keywords(s):
Orthopedics, Radiology
Category(s):
Technology Classifications > Diagnostics, Technology Classifications > Imaging

Small Molecules That Expose HIV Env Sites To Trigger Targeted Immune Killing

This technology uses small molecules to bind HIV Env on infected cells, expose hidden sites, and trigger ADCC, enabling the immune system to kill cells that current therapies cannot reach. By improving antibody recognition and reducing infectious virus production, it provides a complementary approach that directly targets infected cells rather than only preventing new infections.

Published: 12/1/2025
Inventor(s):
Amos Smith, Melissa Grenier-Davies, Andres Finzi, Jean-Philippe Chapleau, Shilei Ding
Keywords(s):
HIV/AIDS
Category(s):
Technology Classifications > Therapeutics, Technology Classifications > Vaccines

PirateNets: Efficient, Scalable, And Robust Neural Network Architecture For Physics-Informed Deep Learning

Physics-Informed Residual Adaptive Networks (PirateNets) is a neural network architecture designed to enable efficient and stable training of deep Physics-Informed Neural Networks (PINNs).

Published: 11/25/2025
Inventor(s):
Paris Perdikaris, Sifan Wang
Keywords(s):
Artificial Intelligence (AI) & Machine Learning, Software
Category(s):
Technology Classifications > Computer Information Systems

A Potent HIV Treatment with Low Toxicity

A small-molecule class that binds to HIV particles to improve immune response and block viral entry into cells.

Published: 11/11/2025
Inventor(s):
Amos Smith, Xuchen Zhao, Tyler Higgins, Andres Finzi, Shilei Ding, Daniel Lee, Marzena Pazgier, Dung Nguyen, William Tolbert
Keywords(s):
Drug Target, HIV/AIDS, Small Molecule, Soft Materials
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics

Novel AKR1C3 Inhibitors in Cancer

Inhibitors and tools to block the local formation of steroid hormones in hormone-dependent malignancies of the prostate, breast and endometrium

Published: 10/30/2025
Inventor(s):
Trevor Penning, Adegoke Adeniji, Michael Byrns, Jeffrey Winkler, Barry Twenter, Lawrence Marnett, Andy Liedtke
Keywords(s):
Men's Health, Oncology, Small Molecule, Women's Health
Category(s):
Technology Classifications > Therapeutics

T Cells Targeting Misformed Proteins to Treat Neurodegenerative and Muscular Diseases

Antigen-specific immunotherapy with engineered cytotoxic T cells targeting misformed proteins to treat neurodegenerative and muscular diseases.

Published: 11/11/2025
Inventor(s):
Ning Jenny Jiang, Shahab Chizari
Keywords(s):
Bioengineering, Cell Therapy, Immunology, Immunotherapy, Inflammation, Neurodegenerative Diseases
Category(s):
Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics

Electronic-Photonic Quadrature Delay-Locked Oscillator (DLO) For Efficient High-Speed Clock Generation And Distribution

A Quadrature Delay-Locked Oscillator that caters to increasing multi-GHz and multi-phase clock demands in systems such as time-interleaved architectures.

Published: 10/29/2025
Inventor(s):
Firooz Aflatouni, Henry Love
Keywords(s):
Artificial Intelligence (AI) & Machine Learning, Electronic Materials, Optics & Photonics 
Category(s):
Technology Classifications > Computer Information Systems, Technology Classifications > Hardware & Components

Human Artificial Chromosome Generation Technology

Technology allowing efficient formation, delivery, isolation, and enrichment of single-copy Human Artificial Chromosome (HAC) for use in research, plant production, gene and cell therapy and more.

Published: 9/19/2025
Inventor(s):
Ben Black, Craig Gambogi, John Glass, David Brown, Gabriel Birchak
Keywords(s):
Bioengineering, Gene Editing, Gene Therapy, Genetic Disorders, Platform Technology
Category(s):
Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
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