Search Results - michael+mitchell

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RGD Peptide-Based Lipids For Targeted mRNA Delivery and Gene Editing Applications

A combinatorial library of RGD peptide (arginine-glycine-aspartic acid)-based lipids designed to formulate lipid nanoparticles for targeted mRNA delivery to the liver and the spleen.

Published: 2/7/2024
Inventor(s):
Michael Mitchell, Lulu Xue, Jingya Qin
Keywords(s):
Bioengineering, Drug Delivery, Gene Editing, Oncology, Platform Technology
Category(s):
Technology Classifications > Therapeutics, Technology Classifications > Vaccines

Ionizable Lipid Nanoparticles For In Vivo mRNA Delivery To The Placenta During Pregnancy

Lipid nanoparticles for selective mRNA delivery to the placenta to treat pre-eclampsia, FGR, and other pregnancy-related disorders.

Published: 2/7/2024
Inventor(s):
Michael Mitchell, Kelsey Swingle
Keywords(s):
Bioengineering, Drug Delivery, Gene Therapy, Platform Technology, Women's Health
Category(s):
Technology Classifications > Therapeutics

Cholesterol Analogues Incorporated Into LNPs For Enhanced mRNA Delivery

Hydroxycholesterols are used to formulate lipid nanoparticles (LNPs) for enhanced mRNA delivery into T cells.

Published: 2/6/2024
Inventor(s):
Michael Mitchell, Margaret Billingsley, Savan Patel, Xuexiang Han, Hanwen Zhang
Keywords(s):
Bioengineering, Cell Therapy, Drug Delivery, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Immunoncology, Immunotherapy, Inflammation, Nanotechnology, Platform Technology
Category(s):
Technology Classifications > Therapeutics

Amniotic Fluid Stabilized Lipid Nanoparticles (LNPs) for In Utero Intra-Amniotic mRNA Delivery

Nanoparticles for potent encapsulation and delivery of therapeutic molecules for prenatal fetal therapy in the amniotic sac

Published: 2/7/2024
Inventor(s):
Michael Mitchell, Kelsey Swingle, Margaret Billingsley, William Peranteau
Keywords(s):
Bioengineering, Cell Therapy, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Nanotechnology, Orphan Disease, Platform Technology
Category(s):
Technology Classifications > Therapeutics

Modified Lipid Nanoparticle Formulations with Improved Therapeutic Delivery to the Bone Microenvironment In-vivo

A library of bi-phosphonate ionizable lipids and LNP formulations to facilitate mRNA delivery to the bone microenvironment. 

Published: 2/7/2024
Inventor(s):
Michael Mitchell, Lulu Xue
Keywords(s):
Drug Delivery, Drug Target, Nanotechnology, Orthopedics, Platform Technology, Regenerative Medicine
Category(s):
Technology Classifications > Vaccines, Technology Classifications > Therapeutics, Technology Classifications > Research Tools & Reagents

Ligand-Tethered Lipid Nanoparticles for Targeted RNA Delivery to Treat Liver Fibrosis

A new class of anisimide-functionalized lipids that enables targeted delivery of lipid nanoparticles (LNPs) to activated fibroblasts in the liver.

Published: 2/7/2024
Inventor(s):
Michael Mitchell, Xuexiang Han
Keywords(s):
Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Immunoncology, Platform Technology, Regenerative Medicine
Category(s):
Technology Classifications > Therapeutics, Technology Classifications > Vaccines

Microfluidic device for large-scale production of lipid nanoparticles

A scalable, parallelized, multi-channel microfluidic device for generating lipid nanoparticles.

Published: 10/16/2023
Inventor(s):
Michael Mitchell, David Issadore, Sarah Shepherd, Sagar Yadavali
Keywords(s):
Bioengineering, Drug Delivery, Microfluidics, Nanotechnology
Category(s):
Technology Classifications > Therapeutics, Technology Classifications > Materials

Lipid nanoparticle-based mRNA delivery for CAR T-cell engineering

A library of ionizable lipid nanoparticles (LNPs) was screened for ability to deliver mRNA to T-cells, leading to an optimized LNP formulation for delivery of mRNA to T-cells. This thereby enhances the ability to generate transient chimeric antigen receptor (CAR)-expressing T-cells for cancer immunotherapy.

Published: 1/23/2024
Inventor(s):
Margaret Billingsley, Carl June, Nathan Singh, Michael Mitchell
Keywords(s):
Bioengineering, COVID-19, Drug Delivery, Immunology, Immunotherapy
Category(s):
Technology Classifications > Therapeutics

Rapid Method to Design and Screen Novel Lipid Nanoparticles for mRNA Delivery In Vivo

A platform technology to rapidly identify novel lipid nanoparticle (LNP) formulations to carry mRNA-based therapeutics to target organs/cells in vivo.

Published: 1/23/2024
Inventor(s):
Michael Mitchell, Rui Zhang, Roman Spektor
Keywords(s):
Bioengineering, COVID-19
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics