Search Results - immunotherapy

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T Cells Targeting Misformed Proteins to Treat Neurodegenerative and Muscular Diseases

Antigen-specific immunotherapy with engineered cytotoxic T cells targeting misformed proteins to treat neurodegenerative and muscular diseases.

Published: 11/11/2025
Inventor(s):
Ning Jenny Jiang, Shahab Chizari
Keywords(s):
Bioengineering, Cell Therapy, Immunology, Immunotherapy, Inflammation, Neurodegenerative Diseases
Category(s):
Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics

Reducing The Adverse Side Effects Of Using Native T-Cells To Destroy Cancer Cells

A Switchable Bispecific T-Cell Nanoengager (sBiTNE) to link T cells with cancer cells that can be reversed if off-tumor toxicity is detected.

Published: 10/10/2025
Inventor(s):
Michael Mitchell, Ningqiang Gong
Keywords(s):
Bioengineering, Immunology, Immunoncology, Immunotherapy, Oncology, Platform Technology, Protein/Peptide (Non-Antibody), Small Molecule
Category(s):
Technology Classifications > Therapeutics

Anticancer IgG Against Multiple Epitopes on Live Tumors Upon Disruption of ‘Self’ Signaling by CD47

A method to combine two or three monoclonal antibodies (mABs) into one treatment to successfully bind to multiple cancer cell surface epitopes and promote targeted degradation by phagocytosis.

Published: 2/27/2025
Inventor(s):
Dennis Discher, Jason Andrechak, Lawrence Dooling
Keywords(s):
Antibody, Bioengineering, Cell Therapy, Drug Target, Immunology, Immunoncology, Immunotherapy, Oncology, Platform Technology
Category(s):
Technology Classifications > Therapeutics

T-Cell-Activating Lipid Nanoparticles for Rapid Engineering of CAR T Cells

A method to streamline the process of generating chimeric antigen receptor (CAR) T cells for therapeutic applications.

Published: 11/26/2025
Inventor(s):
Ann Metzloff, Margaret Billingsley, Michael Mitchell
Keywords(s):
Bioengineering, Cell Therapy, Drug Delivery, Immunoncology, Immunotherapy, Oncology, Platform Technology
Category(s):
Technology Classifications > Therapeutics

Method to Alleviate Side Effects of CAR T Cell Immunotherapies

CAR-T cells are PEGylated to block the interactions with monocytes and macrophages to reduce the side effects of CAR-T cell therapies (cytokine release syndrome and neurotoxicity).

Published: 10/3/2025
Inventor(s):
Michael Mitchell, Ningqiang Gong
Keywords(s):
Bioengineering, Cell Therapy, Immunology, Immunoncology, Immunotherapy, Oncology
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics

Safe and Potent mRNA Lipid Nanoparticles (LNPs) for Ex-Vivo Engineering of Immunosuppressive T cells in Autoimmunity Therapies.

Using mRNA-LNPs to deliver forkhead box protein 3 (Foxp3) to CD4+ T cells to engineer Foxp3-positive T (FP3T) cells with immunosuppressive properties.

Published: 11/26/2025
Inventor(s):
Michael Mitchell, Ajay Thatte, Alvin Mukalel
Keywords(s):
Bioengineering, Cell Therapy, Drug Delivery, Immunology, Immunotherapy, Platform Technology
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics

Immune Modulator Encoded Lipid Nanoparticle Formulation Improves T Cell Response to Vaccines

Researchers developed an LNP-mRNA-based vaccine that encodes different cytokine mRNAs, as a method to enhance CD8+ T cell responses and memory formation.

Published: 9/8/2025
Inventor(s):
Christopher Hunter, Drew Weissman, Mohamad-Gabriel Alameh, Emily Aunins, Anthony Phan
Keywords(s):
Bioengineering, Drug Delivery, Immunology, Immunoncology, Immunotherapy, Infectious Disease, Nanotechnology
Category(s):
Technology Classifications > Therapeutics, Technology Classifications > Vaccines

Compositions and Methods for Enhancing the Anti-Tumor Activity of CAR T Cells by Co-Expression of CH25H

Co-expression of modified chimeric antigen receptor (CAR) T cells and cholesterol 25-hydroxylase (CH25H) in a single construct for treatment of solid tumor and hematological cancers. 

Published: 8/27/2025
Inventor(s):
Serge Fuchs, Noreen McBrearty, Zhen Lu
Keywords(s):
Bioengineering, CAR T-cell Enhancing Technology, Cell Therapy, Immunoncology, Immunotherapy, Oncology, Platform Technology
Category(s):
Technology Classifications > Therapeutics

CD137 enrichment of tumor-specific tumor-infiltrating lymphocytes (TILs)

A platform to isolate and expand CD137-positive (CD137pos) tumor-infiltrating lymphocytes (TILs) to use in adoptive immunotherapy and translational studies.

Published: 4/25/2025
Inventor(s):
Daniel Powell
Keywords(s):
CAR T-cell Enhancing Technology, Cell Therapy, Immunology, Immunoncology, Immunotherapy, Oncology, Platform Technology
Category(s):
Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics, Technology Classifications > Vaccines

Adoptive T cell therapy for cancer using Mutant KRAS-specific T cell receptors for T cell engineering

We have isolated, cloned, and characterized multiple T cell receptors (TCRs) from human donors specific for common mutations in KRAS and restricted to highly prevalent HLA types.  These TCRs, protected by a Penn provisional filing, are suitable for T cell engineering for the adoptive immunotherapy of cancer patients of select HLA types and tumors expressing particular KRAS mutantions.

The comprehensive bioinformatics, biochemical and immunological assessment of these TCRs is in press (Bear et al, Nature Communications).

Published: 3/4/2025
Inventor(s):
Adham Bear, Robert Vonderheide, Gerald Linette, Beatriz Carreno
Keywords(s):
Cell Therapy, Immunology, Immunotherapy, Oncology
Category(s):
Technology Classifications > Therapeutics
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