Search Results - orthopedics

14 Results
Sort By:

DREAMER: Single-Scan, Multi-Contrast 3D Magnetic Resonance Imaging of Solid and Soft Tissue

A rapid, radiation-free magnetic resonance imaging (MRI) method that simultaneously captures bone-selective (pseudo-CT) bone images and high-resolution T1- and T2-weighted soft-tissue images in a single, self-registered 3D scan.

Published: 12/4/2025
Inventor(s):
Chamith Rajapakse, Brian-Tinh Duc Vu, Felix Wehrli, Nada Kamona
Keywords(s):
Orthopedics, Radiology
Category(s):
Technology Classifications > Diagnostics, Technology Classifications > Imaging

DNA Secondary Structure (G-quadruplex) Stabilizers Improve Muscle Repair in Acute Injuries, Exercise, and Aging

Essential stem cell maintenance genes, including Pax7, a transcription factor fundamental to preserving the high regenerative capacity of muscles, is induced via targeting DNA secondary structures.

Published: 8/5/2025
Inventor(s):
Foteini Mourkioti, Ji-Hyung Lee
Keywords(s):
Aging, Drug Target, Orthopedics, Regenerative Medicine, Small Molecule
Category(s):
Technology Classifications > Therapeutics

Biocompatible And Low-Toxicity Lipid Nanoparticles (LNPs) For Selectively Delivering mRNA To The Bone Microenvironment

Ionizable LNPs with a rigid backbone of piperazine (PIP) linked to bisphosphonates (BPs) for the targeted delivery of mRNA to the bone.

Published: 10/3/2025
Inventor(s):
Michael Mitchell, Kyle Vining, Lulu Xue, Il-Chul Yoon
Keywords(s):
Aging, Bioengineering, Drug Delivery, Gene Therapy, Orthopedics, Platform Technology, Women's Health
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics

New Paradigm of Using Hypoxia-Promoting Therapeutics for Enhancing Bone Fracture Repair

Modulate oxygen-releasing erythroid progenitor cells (EPCs) to promote low oxygen conditions (hypoxia) and enhance bone fracture repair.

Published: 8/5/2025
Inventor(s):
Annemarie Lang, Joel Boerckel
Keywords(s):
Bioengineering, Orthopedics, Regenerative Medicine
Category(s):
Technology Classifications > Therapeutics

Augmented Reality Interface for Radiation-Free Screw Insertion during Intramedullary Nail Insertion for Long Bone Fractures

The NailedIt Augmented Reality (AR) Surgical Navigation System, comprised of a Windows-based desktop application, augmented reality headsets (HMDs) worn by surgeons, handheld mobile devices supporting remote viewing and surgical site annotation, and spatially tracked medical devices and instruments, assists and guides surgeons while they perform orthopedic surgical tasks using an immersive augmented reality user interface.

Published: 9/8/2025
Inventor(s):
Thomas Schaer, Stephen Lane, Samir Mehta
Keywords(s):
Augmented Reality (AR) & Virtual Reality (VR), Orthopedics, Platform Technology, Software, Surgery
Category(s):
Technology Classifications > Medical Devices

Suture Device for Rotator Cuff Surgery in Patients with Osteoporosis

An integrated device for anchor replacement and biologic cement injection during rotator cuff repair.

Published: 8/5/2025
Inventor(s):
Andrew Parambath, John Kelly, IV, Alexander Lee, Ali Farooqi
Keywords(s):
Bioengineering, Orthopedics, Surgery
Category(s):
Technology Classifications > Hardware & Components, Technology Classifications > Medical Devices

Spine TK: Deep Learning AI Toolkit for Spine Health Assessment

Fast quantification of spine fractures, curvature, vertebral deformities, vertebral texture, vertebral strength, bone density, and intervertebral disk measurements using CT, MR, DXA, PET, or X-ray images for evaluation of spine health and surgery planning.

Published: 6/5/2024
Inventor(s):
Chamith Rajapakse
Keywords(s):
Artificial Intelligence (AI) & Machine Learning, Orthopedics, Radiology, Software
Category(s):
Technology Classifications > Diagnostics, Technology Classifications > Imaging

Accurate Blood Biomarkers for Early Diagnosis of Synovial Joint Disease in the Mucopolysaccharidoses

Ten candidate serum and synovial protein levels provide early indication of joint impairment in lysosomal storage disorders.

Published: 8/5/2025
Inventor(s):
Lachlan Smith, Chenghao Zhang
Keywords(s):
Bioengineering, Cell Therapy, Drug Target, Genetic Disorders, Inflammation, Orthopedics, Regenerative Medicine
Category(s):
Technology Classifications > Diagnostics, Technology Classifications > Testing & Measurement

Modified Lipid Nanoparticle Formulations with Improved Therapeutic Delivery to the Bone Microenvironment In-vivo

A library of bi-phosphonate ionizable lipids and LNP formulations to facilitate mRNA delivery to the bone microenvironment. 

Published: 11/26/2025
Inventor(s):
Michael Mitchell, Lulu Xue
Keywords(s):
Drug Delivery, Drug Target, Nanotechnology, Orthopedics, Platform Technology, Regenerative Medicine
Category(s):
Technology Classifications > Vaccines, Technology Classifications > Therapeutics, Technology Classifications > Research Tools & Reagents

Method for Creating Super Resolution Medical Images

The deep learning algorithm retrospectively improves the resolution of routine medical images (e.g., CT, MRI, etc.) without the need for increased radiation or scan time. 

Published: 1/15/2025
Inventor(s):
Chamith Rajapakse
Keywords(s):
Aging, Artificial Intelligence (AI) & Machine Learning, Cell Therapy, Orthopedics, Radiology, Software
Category(s):
Technology Classifications > Imaging
1 2