Search Results - protein%2fpeptide+(non-antibody)

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Highly Selective, Bioengineered Cytokine Reduces Inflammation For Prevention Of Heart Failure After Heart Attack

Targeted delivery of an anti-inflammatory cytokine to prevent heart failure after myocardial infarction.

Published: 7/1/2026
Inventor(s):
Noor Momin, Emily Jacobs
Keywords(s):
Bioengineering, Cardiovascular, Drug Delivery, Drug Target, Immunology, Immunotherapy, Inflammation, Protein/Peptide (Non-Antibody), Pulmonary
Category(s):
Technology Classifications > Therapeutics

Pervious Polymersomes For Antioxidant Enzyme Delivery

Pervious polymersomes encapsulate antioxidant agents while allowing reactive oxygen species to enter through diblock copolymer-defined channels.

Published: 6/11/2026
Inventor(s):
Zhiliang Cheng, Andrew Tsourkas, Ling Qin
Keywords(s):
Drug Delivery, Protein/Peptide (Non-Antibody)
Category(s):
Technology Classifications > Materials, Technology Classifications > Therapeutics

LNP-Enabled Intracellular Delivery of Recombinant bioPROTACs

Recombinant fusion bioPROTACs are combined with cationic delivery agents and lipid formulations to enable cytosolic entry and on-demand intracellular degradation of target proteins.

Published: 6/9/2026
Inventor(s):
Andrew Tsourkas, Alexander Chan
Keywords(s):
Protein/Peptide (Non-Antibody), Soft Materials
Category(s):
Technology Classifications > Therapeutics

Pharmacological Treatment for Sleep Disorders Improving Sleep Quality & Architecture

Targeting Heat Shock Factor 1 (HSF1) via gene therapy or using pharmacological compounds targeting HSF1 (e.g. geranylgeranylacetone or macrocyclic peptides) can increase sleep stability, promote deeper sleep, reduce sleep fragmentation, and improve recovery from sleep loss.

Published: 4/16/2026
Inventor(s):
Akhilesh Basi Reddy, Shintaro Yamazaki
Keywords(s):
Aging, Drug Target, Gene Therapy, Neurodegenerative Diseases, Protein/Peptide (Non-Antibody), Small Molecule, Women's Health
Category(s):
Technology Classifications > Therapeutics

An Improved In Vivo Gene-Editing System Using Plug-and-Play Lipid Nanoparticles (LNPs) to Support CRISPR, Small Interfering RNA (siRNA), and Adenine Base Gene Editing Platforms

Simple, plug-and-play biodegradable lipids that form highly potent lipid nanoparticles (LNPs) for CRISPR mRNA delivery, outperforming benchmark gene-editing systems.

Published: 1/14/2026
Inventor(s):
Michael Mitchell, Xuexiang Han, Kelsey Swingle, Alex Hamilton
Keywords(s):
Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Nanotechnology, Platform Technology, Protein/Peptide (Non-Antibody), Small Molecule
Category(s):
Technology Classifications > Therapeutics, Technology Classifications > Vaccines, Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Research Tools & Reagents

Reducing The Adverse Side Effects Of Using Native T-Cells To Destroy Cancer Cells

A Switchable Bispecific T-Cell Nanoengager (sBiTNE) to link T cells with cancer cells that can be reversed if off-tumor toxicity is detected.

Published: 12/8/2025
Inventor(s):
Michael Mitchell, Ningqiang Gong
Keywords(s):
Bioengineering, Immunology, Immunoncology, Immunotherapy, Oncology, Platform Technology, Protein/Peptide (Non-Antibody), Small Molecule
Category(s):
Technology Classifications > Therapeutics

Methods and Sequences for mRNA and Other HIV Vaccine Development

Unique sequences eliciting broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus (HIV) that could be used to develop effective mRNA-based and other types of HIV vaccine.

Published: 6/10/2026
Inventor(s):
George Shaw, Edward (Ted) Kreider, Beatrice Hahn, Ashwin Skelly, Hui Li, Drew Weissman
Keywords(s):
Bioengineering, HIV/AIDS, Immunology, Infectious Disease, Protein/Peptide (Non-Antibody)
Category(s):
Technology Classifications > Vaccines

Deep Learning Model Discovers Antibiotic Drugs in Extinct Organisms Effective Against Drug-Resistant Superbugs

Antibiotic Peptide de-extinction (APEX) is a deep-learning AI solution that can unearth ancient antibiotics to effectively combat superbugs and tackle antibiotic resistance on a global scale.

Published: 1/7/2026
Inventor(s):
Cesar de la Fuente-Nunez, Marcelo Der Torossian Torres, Fangping Wan
Keywords(s):
Bioengineering, Infectious Disease, Platform Technology, Protein/Peptide (Non-Antibody)
Category(s):
Technology Classifications > Therapeutics

Hidden Antibiotics In The Human Proteome For The Treatment Of Antibiotic-Resistant Infections

Antimicrobial peptides computationally mined from the human proteome.

Published: 9/18/2025
Inventor(s):
Cesar de la Fuente-Nunez, Marcelo Der Torossian Torres, Marcelo Dos Reis Melo
Keywords(s):
Bioengineering, Data Science, Infectious Disease, Protein/Peptide (Non-Antibody)
Category(s):
Technology Classifications > Therapeutics

Low Toxicity Antimicrobial Peptides To Overcome Antibiotic Resistance

Combining naturally occurring peptides by hybridizing them with known active peptides to synthesize effective antimicrobial peptides with minimal cytotoxicity.

Published: 1/6/2026
Inventor(s):
Cesar de la Fuente-Nunez, Ravi Radhakrishnan, Vani Xavier de Oliveira Junior, Marcelo Der Torossian Torres, Yiming Wang, Cibele Nicolaski Pedron
Keywords(s):
Infectious Disease, Protein/Peptide (Non-Antibody)
Category(s):
Technology Classifications > Chemical Processes and Synthesis
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