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Gum-health promoting smart dental implant system
Dental implant that inhibits plaque accumulation and gingival tissue inflammation by photobiomodulation therapy delivered by embedded light-emitting diodes (LEDs) powered by electricity generated from the patient’s own oral motion. Problem: More than half of adults will lose one or more teeth in their lifetime. When a patient loses a tooth the...
Published:
2/9/2021
Inventor(s):
Geelsu Hwang
,
Hye-Eun Kim
,
Albert Kim
Keywords(s):
Bioengineering
,
Cell Therapy
,
Dentistry
,
Immunology
,
Immunoncology
,
Infectious Disease
,
Inflammation
Category(s):
Medical Devices
High performance CRISPR-Cas12a system for combinatorial genetic manipulation
CRISPR-Cas12a allowing for simultaneous editing of multiple genes in mammalian cells Problem: CRISPR-based gene editing technique has revolutionized the field of molecular biology. While CRISPR-Cas9-based methods are effectively used for single-gene knockout, multiplex gene editing remains a major challenge. Unlike Cas9, Cas12a can be used for multigene...
Published:
11/5/2020
Inventor(s):
Junwei Shi
,
Rodrigo Gier
Keywords(s):
Cell Therapy
,
Gene Therapy
,
Immunoncology
Category(s):
Research Tools & Reagents
Novel inhibitors of ferroptosis
Novel derivatives of oleic acid effectively inhibiting ferroptosis that could be used for treatment of Friedreich Ataxia, neurodegenerative diseases, and neuropsychiatric diseases. Problem: Ferroptosis is a non-apoptotic form of cell death characterized by the iron-dependent accumulation of toxic lipid-reactive oxygen species. Ferroptosis has been...
Published:
10/16/2020
Inventor(s):
Robert Wilson
,
Maria Cotticelli
,
Shujuan Xia
,
Donna Huryn
,
Amos Smith
,
Taehee Lee
,
Roberto Forestieri
Keywords(s):
Antibody
,
Cell Therapy
,
Immunology
,
Immunoncology
,
Oncology
Category(s):
Therapeutics & Vaccines
Rapid and ultrasensitive profiling of EGFRvIII mutations in cancer and normal tissue
A method to rapidly detect the presence of EGFRvIII mutations in cancers and normal tissue using digital PCR. Problem: Glioblastoma multiforme (GBM) is a devastating brain cancer with poor prognosis. EGFRvIII is a mutation in the Extracellular Growth Factor Receptor that frequently occurs in GBM tumors. Targeting EGFRvIII mutations is an emerging...
Published:
10/5/2020
Inventor(s):
Deeksha Saxena
,
Jay Dorsey
,
Gary Kao
,
Donald O'Rourke
,
Maclean Nasrallah
Keywords(s):
Cell Therapy
,
Immunoncology
,
Oncology
Category(s):
Chemical Processes and Synthesis
,
Diagnostics
,
Research Tools & Reagents
Fully human anti-mesothelin CAR with low immunogenicity for in vivo persistence of anti-tumor engineered T cells
The fully human CAR targets mesothelin, a surface protein overexpressed in several cancer types. P4, a human antibody fragment that binds human mesothelin with high specificity, is fused to T cell signaling domains such as 28z. The T cells engineered to express this CAR are shown to shrink tumors in a mouse model bearing human ovarian tumors overexpressing...
Published:
1/29/2020
Inventor(s):
Daniel Powell
Keywords(s):
Antibody
,
Cell Therapy
,
Immunology
,
Immunoncology
,
Oncology
Category(s):
Therapeutics & Vaccines