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Method for distinguishing “DNA-trapping” and “Non-trapping” PARP inhibitors

Methodology by which to identify candidate PARP inhibitors with strong anti-cancer properties (i.e. “trapping” compounds), as well as PARP inhibitors with low cellular toxicity for treatment of stroke, diabetes, myocardial infarction, neurodegenerative diseases and other diseases (i.e. a “non-trapping” compounds) Overview...

Published: 7/29/2019

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Novel “DNA trapping” and “Non-trapping” PARP Inhibitors

Candidate PARPi compounds with strong anti-cancer capabilities (i.e. “DNA trappers”) and PARPi candidates with low cellular toxicity for treatment of stroke, diabetes, myocardial infarction, neurodegenerative diseases and other diseases with PARP overactivation (i.e. “non-trappers”). Technology Overview: Inhibition of Poly(ADP‐ribose)...

Published: 6/3/2019

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Rapid, one-step CRISPR/Cas9-based method for simultaneous bi-allelic editing of a gene

Streamlined CRISPR/Cas9 method allowing for differential modification of two alleles of the same gene and generation of new cell lines in a single reaction.Problem: Gene editing using CRISPR/Cas9 system has led to a recent ‘revolution’ in nearly all eukaryotic systems. Most systems where it could be useful (human cells, plants, etc) are...

Published: 2/26/2019

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