Search Results - gerald+linette

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Coherent Generation Of High-Dimensional Structured Light Using A Hyperdimensional Spin-Orbit Microlaser

The current invention describes next-generation high-capacity noise-resilient communication and computing technology. The invention describes a method to coherently generate high-dimensional structured light, including spin-orbit states, in an integrated and scalable way.

Published: 10/16/2023

Adoptive T cell therapy for cancer using Mutant KRAS-specific T cell receptors for T cell engineering

We have isolated, cloned, and characterized multiple T cell receptors (TCRs) from human donors specific for common mutations in KRAS and restricted to highly prevalent HLA types.  These TCRs, protected by a Penn provisional filing, are suitable for T cell engineering for the adoptive immunotherapy of cancer patients of select HLA types and tumors expressing particular KRAS mutantions.

The comprehensive bioinformatics, biochemical and immunological assessment of these TCRs is in press (Bear et al, Nature Communications).

Published: 10/16/2023