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Light-inducible CRISPR-Cas9 dimerization system for engineering 3D chromatin topology
An optogenetic CRISPR-Cas9 system for inducing reversible, three-dimensional chromatin loops to regulate target gene expression. Technology Overview: Mammalian genomes are folded through tens of thousands of chromatin interactions. However, these interactions and the topology of the genome are still poorly understood, especially with respect to...
Published: 2/11/2020   |   Inventor(s): Jennifer Phillips-Cremins
Keywords(s):  
Category(s): Research Tools & Reagents