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Compositions and methods for enhancing the anti-tumor activity of CAR T cells by co-expression of CH25H

Co-expression of modified chimeric antigen receptor (CAR) T cells and cholesterol 25-hydroxylase (CH25H) in a single construct for treatment of solid tumor and hematological cancers. 

Published: 1/23/2024
Inventor(s):
Serge Fuchs, Noreen McBrearty, Zhen Lu
Keywords(s):
Bioengineering, CAR T-cell Enhancing Technology, Cell Therapy, Immunoncology, Immunotherapy, Oncology, Platform Technology
Category(s):
Technology Classifications > Therapeutics