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Safe and Potent mRNA Lipid Nanoparticles (LNPs) for Ex-Vivo Engineering of Immunosuppressive T cells in Autoimmunity Therapies.

Using mRNA-LNPs to deliver forkhead box protein 3 (Foxp3) to CD4+ T cells to engineer Foxp3-positive T (FP3T) cells with immunosuppressive properties.

Published: 10/1/2024
Inventor(s):
Michael Mitchell, Ajay Thatte, Alvin Mukalel
Keywords(s):
Bioengineering, Cell Therapy, Drug Delivery, Immunology, Immunotherapy, Platform Technology
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics