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Biocompatible And Low-Toxicity Lipid Nanoparticles (LNPs) For Selectively Delivering mRNA To The Bone Microenvironment

Ionizable LNPs with a rigid backbone of piperazine (PIP) linked to bisphosphonates (BPs) for the targeted delivery of mRNA to the bone.

Published: 3/7/2025

Inventor(s):

Michael Mitchell, Kyle Vining, Lulu Xue, Il-Chul Yoon

Keywords(s):

Aging, Bioengineering, Drug Delivery, Gene Therapy, Orthopedics, Platform Technology, Women's Health

Category(s):

Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics