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Search Results - andrew+tsourkas

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Site-specific bioconjugation of native immunoglobulins

Method for covalent cross-linking of antibodies to surfaces for immunoassays and targeted drug delivery Technology Overview: The Tsourkas Lab has designed a facile method for the site-specific bioconjugation of native immunoglobulins (IgGs). The researchers have developed novel photoreactive Protein Z variants that allow for the introduction of...

Published: 3/20/2020

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Single step protein purification and site-specific bioconjugation

Sortase-mediated expressed protein ligation and bioconjugation for molecular imaging and targeted therapeutics Technology Overview: The Tsourkas Lab has developed a novel conjugation technique that allows any single-chain recombinant protein to be site-specifically modified at the C-terminus during protein expression and purification procedures....

Published: 3/20/2020

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Optical probes for real-time nucleic acid detection and gene expression analysis in living cells

Fluorescent ratiometric bimolecular beacons with spatiotemporal resolution Problem: Common gene expression analysis methods, including polymerase chain reaction, microarrays, and in situ hybridization rely on fixed or lysed cells, hindering their ability to provide spatiotemporal information. This led to the development of optical probes that enable...

Published: 3/16/2020

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