Search Results - ningqiang+gong

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Reducing The Adverse Side Effects Of Using Native T-Cells To Destroy Cancer Cells

A Switchable Bispecific T-Cell Nanoengager (sBiTNE) to link T cells with cancer cells that can be reversed if off-tumor toxicity is detected.

Published: 4/16/2025
Inventor(s):
Michael Mitchell, Ningqiang Gong
Keywords(s):
Bioengineering, Immunology, Immunoncology, Immunotherapy, Oncology, Platform Technology, Protein/Peptide (Non-Antibody), Small Molecule
Category(s):
Technology Classifications > Therapeutics

Targeted, Enhanced Modification Of Lipid NanoparticlesTto Improve Tumor Therapeutic Efficacy

A method to inhibit small extracellular vesicles (sEVs) released by tumor cells to enhance lipid nanoparticle (LNP) accumulation in tumors.

Published: 4/11/2025
Inventor(s):
Michael Mitchell, Ningqiang Gong, Wenqun Zhong, Wei Guo
Keywords(s):
Bioengineering, Drug Delivery, Immunoncology, Oncology
Category(s):
Technology Classifications > Therapeutics

Method to Alleviate Side Effects of CAR T Cell Immunotherapies

CAR-T cells are PEGylated to block the interactions with monocytes and macrophages to reduce the side effects of CAR-T cell therapies (cytokine release syndrome and neurotoxicity).

Published: 12/20/2024
Inventor(s):
Michael Mitchell, Ningqiang Gong
Keywords(s):
Bioengineering, Cell Therapy, Immunology, Immunoncology, Immunotherapy, Oncology
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics

Ionizable Lipid Nanoparticles with Low Immunogenicity Which Enable Repeated Administrations of mRNAs Encoding Gene Editors, Tumor Neoantigens, and Vaccine Payloads.

Using Mannich reaction-based combinatorial libraries to identify ionizable lipids for low-immunogenic and high-efficiency mRNA delivery.

Published: 10/1/2024
Inventor(s):
Michael Mitchell, Ningqiang Gong
Keywords(s):
Bioengineering, Drug Delivery
Category(s):
Technology Classifications > Therapeutics