Search Results - small+molecule

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Safe and Highly Selective HDAC8 Inhibitors for Kidney Disease and Precision Therapies

HDAC8-targeting small molecules for kidney disease treatment with improved safety, selectivity, and therapeutic potential.

Published: 7/1/2026
Inventor(s):
Donna Huryn, Neil Hukriede, Caroline Consoli
Keywords(s):
Drug Target, Nephrology and Urology, Small Molecule
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics

Improved CD-4 Mimetic Compounds HIV Treatment

Indoline core CD-4 mimetics are a HIV treatment that trick the virus into entering a vulnerable “open” conformation, allowing antibody-dependent cellular toxicity.

Published: 6/25/2026
Inventor(s):
Amos Smith, Christopher Fritschi, Joseph Sodroski
Keywords(s):
HIV/AIDS, Infectious Disease, Small Molecule
Category(s):
Technology Classifications > Therapeutics

Interoceptomimetics: Dietary Supplements to Enhance Exercise Motivation and Performance

Enhancing exercise performance by modulating the activity of motivation-generating brain regions via stimulation of cannabinoid (CB1) receptors of the enteric nervous system.

Published: 4/30/2026
Inventor(s):
Christoph Thaiss, John Nicholas Betley
Keywords(s):
Aging, Cardiovascular, Healthcare IT, Microbiome, Neurology, Obesity Metabolic Disease and Diabetes, Regenerative Medicine, Small Molecule
Category(s):
Technology Classifications > Food Science and Nutrition, Technology Classifications > Therapeutics

Benzofuranoindoline-Containing Fungal RiPP-Derived Anticancer Compounds

Benzofuranoindoline-containing fungal RiPP-derived compounds and analogs, plus pharmaceutical compositions, and administration methods for treating cancers, including leukemia.

Published: 4/16/2026
Inventor(s):
Xue Sherry Gao, Hans Renata, Qiuyue Nie
Keywords(s):
Oncology, Small Molecule
Category(s):
Technology Classifications > Therapeutics

Pharmacological Treatment for Sleep Disorders Improving Sleep Quality & Architecture

Targeting Heat Shock Factor 1 (HSF1) via gene therapy or using pharmacological compounds targeting HSF1 (e.g. geranylgeranylacetone or macrocyclic peptides) can increase sleep stability, promote deeper sleep, reduce sleep fragmentation, and improve recovery from sleep loss.

Published: 4/16/2026
Inventor(s):
Akhilesh Basi Reddy, Shintaro Yamazaki
Keywords(s):
Aging, Drug Target, Gene Therapy, Neurodegenerative Diseases, Protein/Peptide (Non-Antibody), Small Molecule, Women's Health
Category(s):
Technology Classifications > Therapeutics

Selective Receptor Modulators for Skin Depigmentation

Small-molecule compositions modulate non-canonical sex steroid receptors to decrease, prevent, or reverse skin pigmentation gain in mammalian subjects.

Published: 4/6/2026
Inventor(s):
Todd Ridky, Christopher Natale
Keywords(s):
Dermatology, Small Molecule
Category(s):
Technology Classifications > Therapeutics

An Improved In Vivo Gene-Editing System Using Plug-and-Play Lipid Nanoparticles (LNPs) to Support CRISPR, Small Interfering RNA (siRNA), and Adenine Base Gene Editing Platforms

Simple, plug-and-play biodegradable lipids that form highly potent lipid nanoparticles (LNPs) for CRISPR mRNA delivery, outperforming benchmark gene-editing systems.

Published: 1/14/2026
Inventor(s):
Michael Mitchell, Xuexiang Han, Kelsey Swingle, Alex Hamilton
Keywords(s):
Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Nanotechnology, Platform Technology, Protein/Peptide (Non-Antibody), Small Molecule
Category(s):
Technology Classifications > Therapeutics, Technology Classifications > Vaccines, Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Research Tools & Reagents

A Potent HIV Treatment with Low Toxicity

A small-molecule class that binds to HIV particles to improve immune response and block viral entry into cells.

Published: 11/11/2025
Inventor(s):
Amos Smith, Xuchen Zhao, Tyler Higgins, Andres Finzi, Shilei Ding, Daniel Lee, Marzena Pazgier, Dung Nguyen, William Tolbert
Keywords(s):
Drug Target, HIV/AIDS, Small Molecule, Soft Materials
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics

Novel AKR1C3 Inhibitors in Cancer

Inhibitors and tools to block the local formation of steroid hormones in hormone-dependent malignancies of the prostate, breast and endometrium

Published: 10/30/2025
Inventor(s):
Trevor Penning, Adegoke Adeniji, Michael Byrns, Jeffrey Winkler, Barry Twenter, Lawrence Marnett, Andy Liedtke
Keywords(s):
Men's Health, Oncology, Small Molecule, Women's Health
Category(s):
Technology Classifications > Therapeutics

Reducing The Adverse Side Effects Of Using Native T-Cells To Destroy Cancer Cells

A Switchable Bispecific T-Cell Nanoengager (sBiTNE) to link T cells with cancer cells that can be reversed if off-tumor toxicity is detected.

Published: 12/8/2025
Inventor(s):
Michael Mitchell, Ningqiang Gong
Keywords(s):
Bioengineering, Immunology, Immunoncology, Immunotherapy, Oncology, Platform Technology, Protein/Peptide (Non-Antibody), Small Molecule
Category(s):
Technology Classifications > Therapeutics
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