A small-molecule class that binds to HIV particles to improve immune response and block viral entry into cells.
Inhibitors and tools to block the local formation of steroid hormones in hormone-dependent malignancies of the prostate, breast and endometrium
Intranasal delivery of dantrolene nanoparticles can improve motor neuron function, muscle strength, and movement coordination and can offer therapeutic benefits for treatment of Amyotrophic Lateral Sclerosis (ASL).
Essential stem cell maintenance genes, including Pax7, a transcription factor fundamental to preserving the high regenerative capacity of muscles, is induced via targeting DNA secondary structures.
A Switchable Bispecific T-Cell Nanoengager (sBiTNE) to link T cells with cancer cells that can be reversed if off-tumor toxicity is detected.
Targeting retinoic acid (RA) synthesizing enzymes or RA receptors with small molecules boosts the immune system towards a tumor rejection response
Small molecules that bind to alpha-synuclein deposition and can be used for PET imagining in patients with synucleinopathies
A class of pyrazole derivatives that inhibit palmitoyl-transferases, resulting in increasing cancer cell responsiveness to epidermal growth factor receptor inhibitor and KRas mutant lung cancer growth inhibition as a single agent.
Small molecule therapeutics that aid in clearing abnormal protein deposits observed in neurodegenerative diseases.
Compounds are designed to detect and characterize specific RNAs in a cell or sub-cellular compartment using light activation.