Search Results - small+molecule

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Tumor Suppression by Retinoic Acid Pathway Inhibition

Targeting retinoic acid (RA) synthesizing enzymes or RA receptors with small molecules boosts the immune system towards a tumor rejection response  

Published: 6/21/2024
Inventor(s):
Malay Haldar, Ganesha Rai Bantukallu
Keywords(s):
Cell Therapy, Drug Target, Immunology, Immunoncology, Oncology, Small Molecule
Category(s):
Technology Classifications > Therapeutics

PET Radiotracers for Diagnosis and Patient Stratification of Neurodegenerative Disorders

Small molecules that bind to alpha-synuclein deposition and can be used for PET imagining in patients with synucleinopathies

Published: 6/6/2024
Inventor(s):
Robert Mach, E. James Petersson
Keywords(s):
Imaging Agents, Neurodegenerative Diseases, Radiology, Small Molecule
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Diagnostics, Technology Classifications > Imaging, Technology Classifications > Research Tools & Reagents

Pyrazole Derivatives for the Treatment of Lung Cancer Tumors

A class of pyrazole derivatives that inhibit palmitoyl-transferases, resulting in increasing cancer cell responsiveness to epidermal growth factor receptor inhibitor and KRas mutant lung cancer growth inhibition as a single agent.

Published: 5/31/2024
Inventor(s):
George Burslem, Eric Witze
Keywords(s):
Oncology, Small Molecule
Category(s):
Technology Classifications > Therapeutics

Small Molecule Activators of Valosin-Containing Protein (VCP) as Therapeutics for Neurodegenerative Diseases with Ubiquitinated Protein Aggregates

Small molecule therapeutics that aid in clearing abnormal protein deposits observed in neurodegenerative diseases.

Published: 2/9/2024
Inventor(s):
Edward Lee, Benjamin Creekmore, Jessica Phan
Keywords(s):
Aging, Genetic Disorders, Neurodegenerative Diseases, Neurology, Orphan Disease, Small Molecule
Category(s):
Technology Classifications > Therapeutics

Tunable, Caged Molecules For In Vivo and In Situ Transcriptomic Analyses

Compounds are designed to detect and characterize specific RNAs in a cell or sub-cellular compartment using light activation.

Published: 10/16/2023
Inventor(s):
Ivan Dmochowski, James Eberwine, Sean Yeldell, Julianne Griepenburg, Teresa Rapp, Jennifer Singh, Jai-Yoon Sul, Jae Hee Lee
Keywords(s):
Bioengineering, Neurology, Small Molecule
Category(s):
Technology Classifications > Diagnostics, Technology Classifications > Chemical Processes and Synthesis

Treatment for the Prevention of Permanent Vision Loss in Glaucoma Patients

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Published: 1/12/2024
Inventor(s):
Qi Cui, Joshua Dunaief, Jacob Sterling
Keywords(s):
Ophthalmology, Small Molecule
Category(s):
Technology Classifications > Therapeutics

Novel Pyrimidine Derivatives to Treat Alzheimer’s Disease

Brain penetrating compounds as promising therapeutics for treatment of neurodegenerative disorders.

Published: 6/28/2024
Inventor(s):
Kurt Brunden, Carlo Ballatore, Amos Smith, Virginia Lee, John Trojanowski
Keywords(s):
Aging, Neurodegenerative Diseases, Neurology, Small Molecule
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics

Small Molecule Therapeutics for Hematologic Malignancies

Small molecule inhibitors of a key cancer cell signaling pathway cause hematologic cancer cell death, but have low toxicity towards healthy cells.

Published: 6/21/2024
Inventor(s):
Erle Robertson, Wafik El-Deiry, Yonggang Pei, Yanming Du
Keywords(s):
Small Molecule
Category(s):
Technology Classifications > Therapeutics

CD4 mimetic small molecule inhibitors of HIV-1 entry

Therapeutic development for HIV-1 infection and prevention of transmission

Published: 10/16/2023
Inventor(s):
Amos Smith
Keywords(s):
HIV/AIDS, Small Molecule
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics

Small Molecule Antivirals for Therapeutic Applications

Antiviral compounds that competitively disrupt virus-host interactions to inhibit disease progression and transmission

Published: 7/2/2024
Inventor(s):
Ronald Harty
Keywords(s):
Small Molecule
Category(s):
Technology Classifications > Therapeutics