Search Results - hiv%2faids

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Small Molecules That Expose HIV Env Sites To Trigger Targeted Immune Killing

This technology uses small molecules to bind HIV Env on infected cells, expose hidden sites, and trigger ADCC, enabling the immune system to kill cells that current therapies cannot reach. By improving antibody recognition and reducing infectious virus production, it provides a complementary approach that directly targets infected cells rather than only preventing new infections.

Published: 12/1/2025

Inventor(s):

Amos Smith, Melissa Grenier-Davies, Andres Finzi, Jean-Philippe Chapleau, Shilei Ding

Keywords(s):

Category(s):

Technology Classifications > Therapeutics, Technology Classifications > Vaccines

A Potent HIV Treatment with Low Toxicity

A small-molecule class that binds to HIV particles to improve immune response and block viral entry into cells.

Published: 11/11/2025

Inventor(s):

Amos Smith, Xuchen Zhao, Tyler Higgins, Andres Finzi, Shilei Ding, Daniel Lee, Marzena Pazgier, Dung Nguyen, William Tolbert

Keywords(s):

Drug Target, HIV/AIDS, Small Molecule, Soft Materials

Category(s):

Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics

Methods and Sequences for mRNA and Other HIV Vaccine Development

Unique sequences eliciting broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus (HIV) that could be used to develop effective mRNA-based and other types of HIV vaccine.

Published: 8/1/2025

Inventor(s):

George Shaw, Edward (Ted) Kreider, Beatrice Hahn, Ashwin Skelly, Hui Li, Drew Weissman

Keywords(s):

Bioengineering, HIV/AIDS, Immunology, Infectious Disease, Protein/Peptide (Non-Antibody)

Category(s):

Technology Classifications > Vaccines

CD4 mimetic small molecule inhibitors of HIV-1 entry

Therapeutic development for HIV-1 infection and prevention of transmission

Published: 9/26/2025

Inventor(s):

Keywords(s):

HIV/AIDS, Small Molecule

Category(s):

Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics

Accurate, High-Throughput Quantification of HIV Reservoirs Using Optical Scanning

HIV viral protein expression and functional virus reservoir size are rapidly and accurately quantified using optical scanning

Published: 1/11/2024

Inventor(s):

Keywords(s):

Category(s):

Technology Classifications > Diagnostics

A reverse transcription loop-mediated isothermal amplification method to quantify multiple HIV subtypes

A rapid, quantitative point-of-care diagnostics method for viral load detection of HIV-1 clades A, B, C, D, and G

Published: 9/26/2025

Inventor(s):

Haim Bau, Changchun Liu, Frederic Bushman

Keywords(s):

Category(s):

Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Medical Devices

Novel Mouse Lines: A3 Knockout Mice Transgenically Expressing Either A3A or A3G

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Published: 6/5/2024

Inventor(s):

Keywords(s):

Category(s):

Technology Classifications > Research Tools & Reagents

High efficiency, superhydrophobic clamshell plasma separator for point-of-care diagnostics

Membrane-based, sedimentation-assisted plasma separator

Published: 9/26/2025

Inventor(s):

Haim Bau, Changchun Liu, Michael Mauk

Keywords(s):

Category(s):

Technology Classifications > Diagnostics, Technology Classifications > Medical Devices