Search Results - amos+smith

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A Difluoromethylene Linchpin/Synthon For Creating With High Diasteroselectivity

Diverse difluoromethylene scaffolds via novel, organodifluorine synthons.

Published: 10/3/2024
Inventor(s):
Amos Smith, Kevin O'Brien, Jonathan Nadraws
Keywords(s):
 
Category(s):
Technology Classifications > Chemical Processes and Synthesis

Novel Inhibitors of Ferroptosis

Novel derivatives of oleic acid effectively inhibiting ferroptosis that could be used for treatment of Friedreich Ataxia, neurodegenerative diseases, and neuropsychiatric diseases.

Published: 3/13/2024
Inventor(s):
Robert Wilson, Maria Cotticelli, Shujuan Xia, Donna Huryn, Amos Smith, Taehee Lee, Roberto Forestieri
Keywords(s):
Neurodegenerative Diseases
Category(s):
Technology Classifications > Therapeutics

Novel Pyrimidine Derivatives to Treat Alzheimer’s Disease

Brain penetrating compounds as promising therapeutics for treatment of neurodegenerative disorders.

Published: 6/28/2024
Inventor(s):
Kurt Brunden, Carlo Ballatore, Amos Smith, Virginia Lee, John Trojanowski
Keywords(s):
Aging, Neurodegenerative Diseases, Neurology, Small Molecule
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics

Reusable silicon-based cross-coupling agents for the production of natural products, pharmaceuticals, and other organic materials

Cross-coupling reactions without the generation of waste products

Published: 10/16/2023
Inventor(s):
Amos Smith
Keywords(s):
 
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials

CD4 mimetic small molecule inhibitors of HIV-1 entry

Therapeutic development for HIV-1 infection and prevention of transmission

Published: 10/16/2023
Inventor(s):
Amos Smith
Keywords(s):
HIV/AIDS, Small Molecule
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics

A novel isostere to replace the carboxylic acid functional group in pharmaceuticals and other compounds

Cycloalkyl-dione derivatives with improved pharmacokinetic and toxicological properties for drug design

Published: 10/16/2023
Inventor(s):
Amos Smith, Donna Huryn, Carlo Ballatore, Virginia Lee, John Trojanowski
Keywords(s):
 
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials

An efficient method to produce high yield analogs of Hemi-Phorboxazole A with anticancer and antifungal activities

A two-step, high yield, method for synthesizing naturally derived, Hemi-Phorboxazole A analogs

Published: 10/16/2023
Inventor(s):
Amos Smith
Keywords(s):
 
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics

Phorboxazole compounds as potent anti-tumor agents

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Published: 10/16/2023
Inventor(s):
Amos Smith
Keywords(s):
Oncology
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics