Search Results - amos+smith

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Small Molecules That Expose HIV Env Sites To Trigger Targeted Immune Killing

This technology uses small molecules to bind HIV Env on infected cells, expose hidden sites, and trigger ADCC, enabling the immune system to kill cells that current therapies cannot reach. By improving antibody recognition and reducing infectious virus production, it provides a complementary approach that directly targets infected cells rather than only preventing new infections.

Published: 12/1/2025

Inventor(s):

Amos Smith, Melissa Grenier-Davies, Andres Finzi, Jean-Philippe Chapleau, Shilei Ding

Keywords(s):

Category(s):

Technology Classifications > Therapeutics, Technology Classifications > Vaccines

A Potent HIV Treatment with Low Toxicity

A small-molecule class that binds to HIV particles to improve immune response and block viral entry into cells.

Published: 11/11/2025

Inventor(s):

Amos Smith, Xuchen Zhao, Tyler Higgins, Andres Finzi, Shilei Ding, Daniel Lee, Marzena Pazgier, Dung Nguyen, William Tolbert

Keywords(s):

Drug Target, HIV/AIDS, Small Molecule, Soft Materials

Category(s):

Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics

A Difluoromethylene Linchpin/Synthon For Creating With High Diasteroselectivity

Diverse difluoromethylene scaffolds via novel, organodifluorine synthons.

Published: 9/26/2025

Inventor(s):

Amos Smith, Kevin O'Brien, Jonathan Nadraws

Keywords(s):

Category(s):

Technology Classifications > Chemical Processes and Synthesis

Novel Inhibitors of Ferroptosis

Novel derivatives of oleic acid effectively inhibiting ferroptosis that could be used for treatment of Friedreich Ataxia, neurodegenerative diseases, and neuropsychiatric diseases.

Published: 8/1/2025

Inventor(s):

Robert Wilson, Maria Cotticelli, Shujuan Xia, Donna Huryn, Amos Smith, Taehee Lee, Roberto Forestieri

Keywords(s):

Neurodegenerative Diseases

Category(s):

Technology Classifications > Therapeutics

Novel Pyrimidine Derivatives to Treat Alzheimer’s Disease

Brain penetrating compounds as promising therapeutics for treatment of neurodegenerative disorders.

Published: 8/21/2025

Inventor(s):

Kurt Brunden, Carlo Ballatore, Amos Smith, Virginia Lee, John Trojanowski

Keywords(s):

Aging, Neurodegenerative Diseases, Neurology, Small Molecule

Category(s):

Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics

Reusable silicon-based cross-coupling agents for the production of natural products, pharmaceuticals, and other organic materials

Cross-coupling reactions without the generation of waste products

Published: 9/26/2025

Inventor(s):

Keywords(s):

Category(s):

Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials

CD4 mimetic small molecule inhibitors of HIV-1 entry

Therapeutic development for HIV-1 infection and prevention of transmission

Published: 9/26/2025

Inventor(s):

Keywords(s):

HIV/AIDS, Small Molecule

Category(s):

Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics

A novel isostere to replace the carboxylic acid functional group in pharmaceuticals and other compounds

Cycloalkyl-dione derivatives with improved pharmacokinetic and toxicological properties for drug design

Published: 9/26/2025

Inventor(s):

Amos Smith, Donna Huryn, Carlo Ballatore, Virginia Lee, John Trojanowski

Keywords(s):

Category(s):

Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials

An efficient method to produce high yield analogs of Hemi-Phorboxazole A with anticancer and antifungal activities

A two-step, high yield, method for synthesizing naturally derived, Hemi-Phorboxazole A analogs

Published: 9/26/2025

Inventor(s):

Keywords(s):

Category(s):

Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics

Phorboxazole compounds as potent anti-tumor agents

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Published: 9/26/2025

Inventor(s):

Keywords(s):

Category(s):

Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics