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Novel Inhibitors of Ferroptosis
Novel derivatives of oleic acid effectively inhibiting ferroptosis that could be used for treatment of Friedreich Ataxia, neurodegenerative diseases, and neuropsychiatric diseases.Problem: Ferroptosis is a non-apoptotic form of cell death characterized by the iron-dependent accumulation of toxic lipid-reactive oxygen species. Ferroptosis has been suggested...
Published: 10/16/2020   |   Inventor(s): Robert Wilson, Maria Cotticelli, Shujuan Xia, Donna Huryn, Amos Smith, Taehee Lee, Roberto Forestieri
Keywords(s): Antibody, Autoimmune, Cell Therapy, Immunology, Immunoncology, Oncology
Category(s): Therapeutics & Vaccines
Reusable silicon-based cross-coupling agents for the production of natural products, pharmaceuticals, and other organic materials
Cross-coupling reactions without the generation of waste products Problem: Catalytic carbon-carbon bond formation based on cross-coupling reactions (CCRs) plays a central role in the production of natural products, pharmaceuticals, agrochemicals, and organic materials. Coupling reactions with organometallic reagents and organic halides facilitate...
Published: 3/20/2020   |   Inventor(s): Amos Smith
Keywords(s):  
Category(s): Chemical Processes and Synthesis, Materials, Research Tools & Reagents, Therapeutics & Vaccines
CD4 mimetic small molecule inhibitors of HIV-1 entry
Therapeutic development for HIV-1 infection and prevention of transmission Problem: A global pandemic of human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) persists, with about 34 million people worldwide currently infected and 2.5 million people newly infected with the virus annually. Inhibition of the initial...
Published: 3/19/2020   |   Inventor(s): Amos Smith
Keywords(s):  
Category(s): Chemical Processes and Synthesis, Therapeutics & Vaccines
A novel isostere to replace the carboxylic acid functional group in pharmaceuticals and other compounds
Cycloalkyl-dione derivatives with improved pharmacokinetic and toxicological properties for drug design Problem: Isosteric replacement of a specific group of atoms with a moiety with similar physicochemical properties is a strategy employed by medicinal chemists to improve the properties of biologically active compounds. For example, carboxylic...
Published: 3/19/2020   |   Inventor(s): Amos Smith, Donna Huryn, Carlo Ballatore, Virginia Lee, John Trojanowski
Keywords(s):  
Category(s): Chemical Processes and Synthesis, Materials, Therapeutics & Vaccines
An efficient method to produce high yield analogs of Hemi-Phorboxazole A with anticancer and antifungal activities
A two-step, high yield, method for synthesizing naturally derived, Hemi-Phorboxazole A analogs Problem: (+)-Phorboxazole A and B, extracted from the sponge Phorbas sp., display extraordinary anti-proliferative activity against National Cancer Institute’s (NCI) panel of 60 human tumor cell lines. Due to their complex structures, the reported...
Published: 3/17/2020   |   Inventor(s): Amos Smith
Keywords(s):  
Category(s): Chemical Processes and Synthesis, Therapeutics & Vaccines
Phorboxazole compounds as potent anti-tumor agents
Problem: Phorboxazoles are naturally occurring compounds that have been isolated from the marine sponge Phorbas, endemic to the western coast of Australia. Previous screens of phorboxazoles against the National Cancer Institute human cell line panel indicated the most potent cytotoxicity assayed. While the mechanism of action in vivo is unknown,...
Published: 3/5/2020   |   Inventor(s): Amos Smith
Keywords(s): Oncology
Category(s): Chemical Processes and Synthesis, Therapeutics & Vaccines