Search Results - amos+smith

Improved CD-4 Mimetic Compounds HIV Treatment

Indoline core CD-4 mimetics are a HIV treatment that trick the virus into entering a vulnerable “open” conformation, allowing antibody-dependent cellular toxicity.

Published: 6/25/2026

Small-Molecule Therapeutic for Stabilizing HIV-1 Envelope Proteins to Increase Immune Response

Small-molecule inhibitor that prolongs exposure of HIV-1 to broadly neutralizing antibodies to suppress viral entry and infection

Published: 6/25/2026

Inventor(s):

Amos Smith, Althea Lang, Joseph Sodroski

Keywords(s):

Drug Target, HIV/AIDS, Immunology, Infectious Disease

Category(s):

Technology Classifications > Therapeutics, Technology Classifications > Chemical Processes and Synthesis

Small Molecules That Expose HIV Env Sites To Trigger Targeted Immune Killing

This technology uses small molecules to bind HIV Env on infected cells, expose hidden sites, and trigger ADCC, enabling the immune system to kill cells that current therapies cannot reach. By improving antibody recognition and reducing infectious virus production, it provides a complementary approach that directly targets infected cells rather than only preventing new infections.

Published: 12/1/2025

Inventor(s):

Amos Smith, Melissa Grenier-Davies, Andres Finzi, Jean-Philippe Chapleau, Shilei Ding

Keywords(s):

HIV/AIDS

Category(s):

Technology Classifications > Therapeutics, Technology Classifications > Vaccines

A Potent HIV Treatment with Low Toxicity

A small-molecule class that binds to HIV particles to improve immune response and block viral entry into cells.

Published: 11/11/2025

Inventor(s):

Amos Smith, Xuchen Zhao, Tyler Higgins, Andres Finzi, Shilei Ding, Daniel Lee, Marzena Pazgier, Dung Nguyen, William Tolbert

Keywords(s):

Drug Target, HIV/AIDS, Small Molecule, Soft Materials

Category(s):

Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics

A Difluoromethylene Linchpin/Synthon For Creating With High Diasteroselectivity

Diverse difluoromethylene scaffolds via novel, organodifluorine synthons.

Published: 9/26/2025

Inventor(s):

Amos Smith, Kevin O'Brien, Jonathan Nadraws

Keywords(s):

Category(s):

Technology Classifications > Chemical Processes and Synthesis

Novel Inhibitors of Ferroptosis

Novel derivatives of oleic acid effectively inhibiting ferroptosis that could be used for treatment of Friedreich Ataxia, neurodegenerative diseases, and neuropsychiatric diseases.