Search Results - margaret+billingsley

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T-Cell-Activating Lipid Nanoparticles for Rapid Engineering of CAR T Cells

A method to streamline the process of generating chimeric antigen receptor (CAR) T cells for therapeutic applications.

Published: 12/20/2024

Inventor(s):

Ann Metzloff, Margaret Billingsley, Michael Mitchell

Keywords(s):

Bioengineering, Cell Therapy, Drug Delivery, Immunoncology, Immunotherapy, Oncology, Platform Technology

Category(s):

Technology Classifications > Therapeutics

Cholesterol Analogues Incorporated Into LNPs For Enhanced mRNA Delivery

Hydroxycholesterols are used to formulate lipid nanoparticles (LNPs) for enhanced mRNA delivery into T cells.

Published: 2/6/2024

Inventor(s):

Michael Mitchell, Margaret Billingsley, Savan Patel, Xuexiang Han, Hanwen Zhang

Keywords(s):

Bioengineering, Cell Therapy, Drug Delivery, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Immunoncology, Immunotherapy, Inflammation, Nanotechnology, Platform Technology

Category(s):

Technology Classifications > Therapeutics

Amniotic Fluid Stabilized Lipid Nanoparticles (LNPs) for In Utero Intra-Amniotic mRNA Delivery

Nanoparticles for potent encapsulation and delivery of therapeutic molecules for prenatal fetal therapy in the amniotic sac

Published: 2/7/2024

Inventor(s):

Michael Mitchell, Kelsey Swingle, Margaret Billingsley, William Peranteau

Keywords(s):

Bioengineering, Cell Therapy, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Nanotechnology, Orphan Disease, Platform Technology

Category(s):

Technology Classifications > Therapeutics

Lipid nanoparticle-based mRNA delivery for CAR T-cell engineering

A library of ionizable lipid nanoparticles (LNPs) was screened for ability to deliver mRNA to T-cells, leading to an optimized LNP formulation for delivery of mRNA to T-cells. This thereby enhances the ability to generate transient chimeric antigen receptor (CAR)-expressing T-cells for cancer immunotherapy.

Published: 1/23/2024

Inventor(s):

Margaret Billingsley, Carl June, Nathan Singh, Michael Mitchell

Keywords(s):

Bioengineering, COVID-19, Drug Delivery, Immunology, Immunotherapy

Category(s):

Technology Classifications > Therapeutics