Search Results - kelsey+swingle

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An Improved In Vivo Gene-Editing System Using Plug-and-Play Lipid Nanoparticles (LNPs) to Support CRISPR, Small Interfering RNA (siRNA), and Adenine Base Gene Editing Platforms

Simple, plug-and-play biodegradable lipids that form highly potent lipid nanoparticles (LNPs) for CRISPR mRNA delivery, outperforming benchmark gene-editing systems.

Published: 1/14/2026
Inventor(s):
Michael Mitchell, Xuexiang Han, Kelsey Swingle, Alex Hamilton
Keywords(s):
Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Nanotechnology, Platform Technology, Protein/Peptide (Non-Antibody), Small Molecule
Category(s):
Technology Classifications > Therapeutics, Technology Classifications > Vaccines, Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Research Tools & Reagents

Ionizable Lipid Nanoparticles For In Vivo mRNA Delivery To The Placenta During Pregnancy

Lipid nanoparticles for selective mRNA delivery to the placenta to treat pre-eclampsia, FGR, and other pregnancy-related disorders.

Published: 12/8/2025
Inventor(s):
Michael Mitchell, Kelsey Swingle
Keywords(s):
Bioengineering, Drug Delivery, Gene Therapy, Platform Technology, Women's Health
Category(s):
Technology Classifications > Therapeutics

Amniotic Fluid Stabilized Lipid Nanoparticles (LNPs) for In Utero Intra-Amniotic mRNA Delivery

Nanoparticles for potent encapsulation and delivery of therapeutic molecules for prenatal fetal therapy in the amniotic sac

Published: 10/3/2025
Inventor(s):
Michael Mitchell, Kelsey Swingle, Margaret Billingsley, William Peranteau
Keywords(s):
Bioengineering, Cell Therapy, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Nanotechnology, Orphan Disease, Platform Technology
Category(s):
Technology Classifications > Therapeutics